Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration

P. A. Aspinall; A. R. Hill; B. Dhillon; A. M. Armbrecht; P. Nelson; C. Lumsden; E. Farini-Hudson; R. Brice; A. Vickers; P. Buchholz

doi:10.1136/bjo.2006.104679

Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration

P. A. Aspinall, A. R. Hill, B. Dhillon, A. M. Armbrecht, P. Nelson, C. Lumsden, E. Farini-Hudson, R. Brice, A. Vickers, P. Buchholz

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Aim: To investigate the relative priorities in quality of life (QoL) in patients with age-related macular degeneration (AMD). Methods: Measures of visual function, QoL and utility associated with visual loss were obtained from 122 patients with AMD classified according to macular morphology. The two methods of utility assessment were time trade-off (TTO) and conjoint analysis (CA), which have been recommended by the UK's National Institute of Clinical Excellence as techniques for the assessment of healthcare priorities. Results: Results show that the two methods for assessing utility are poorly related: TTO relates moderately to visual function and disease severity but CA does not. CA identified two different subgroups of patients: one with outdoor mobility and the other with reading as their main priority. Conclusion: Further work is needed and caution required in interpreting data obtained using these methodologies for determining their relative importance in vision-related QoL studies.

Original language	English
Pages (from-to)	766-772
Number of pages	7
Journal	British Journal of Ophthalmology
Volume	91
Issue number	6
DOIs	https://doi.org/10.1136/bjo.2006.104679
Publication status	Published - Jun 2007

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Aspinall, P. A., Hill, A. R., Dhillon, B., Armbrecht, A. M., Nelson, P., Lumsden, C., Farini-Hudson, E., Brice, R., Vickers, A., & Buchholz, P. (2007). Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration. British Journal of Ophthalmology, 91(6), 766-772. https://doi.org/10.1136/bjo.2006.104679

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title = "Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration",

abstract = "Aim: To investigate the relative priorities in quality of life (QoL) in patients with age-related macular degeneration (AMD). Methods: Measures of visual function, QoL and utility associated with visual loss were obtained from 122 patients with AMD classified according to macular morphology. The two methods of utility assessment were time trade-off (TTO) and conjoint analysis (CA), which have been recommended by the UK's National Institute of Clinical Excellence as techniques for the assessment of healthcare priorities. Results: Results show that the two methods for assessing utility are poorly related: TTO relates moderately to visual function and disease severity but CA does not. CA identified two different subgroups of patients: one with outdoor mobility and the other with reading as their main priority. Conclusion: Further work is needed and caution required in interpreting data obtained using these methodologies for determining their relative importance in vision-related QoL studies.",

author = "Aspinall, {P. A.} and Hill, {A. R.} and B. Dhillon and Armbrecht, {A. M.} and P. Nelson and C. Lumsden and E. Farini-Hudson and R. Brice and A. Vickers and P. Buchholz",

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Aspinall, PA, Hill, AR, Dhillon, B, Armbrecht, AM, Nelson, P, Lumsden, C, Farini-Hudson, E, Brice, R, Vickers, A & Buchholz, P 2007, 'Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration', British Journal of Ophthalmology, vol. 91, no. 6, pp. 766-772. https://doi.org/10.1136/bjo.2006.104679

TY - JOUR

T1 - Quality of life and relative importance

T2 - A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration

AU - Aspinall, P. A.

AU - Hill, A. R.

AU - Dhillon, B.

AU - Armbrecht, A. M.

AU - Nelson, P.

AU - Lumsden, C.

AU - Farini-Hudson, E.

AU - Brice, R.

AU - Vickers, A.

AU - Buchholz, P.

PY - 2007/6

Y1 - 2007/6

N2 - Aim: To investigate the relative priorities in quality of life (QoL) in patients with age-related macular degeneration (AMD). Methods: Measures of visual function, QoL and utility associated with visual loss were obtained from 122 patients with AMD classified according to macular morphology. The two methods of utility assessment were time trade-off (TTO) and conjoint analysis (CA), which have been recommended by the UK's National Institute of Clinical Excellence as techniques for the assessment of healthcare priorities. Results: Results show that the two methods for assessing utility are poorly related: TTO relates moderately to visual function and disease severity but CA does not. CA identified two different subgroups of patients: one with outdoor mobility and the other with reading as their main priority. Conclusion: Further work is needed and caution required in interpreting data obtained using these methodologies for determining their relative importance in vision-related QoL studies.

AB - Aim: To investigate the relative priorities in quality of life (QoL) in patients with age-related macular degeneration (AMD). Methods: Measures of visual function, QoL and utility associated with visual loss were obtained from 122 patients with AMD classified according to macular morphology. The two methods of utility assessment were time trade-off (TTO) and conjoint analysis (CA), which have been recommended by the UK's National Institute of Clinical Excellence as techniques for the assessment of healthcare priorities. Results: Results show that the two methods for assessing utility are poorly related: TTO relates moderately to visual function and disease severity but CA does not. CA identified two different subgroups of patients: one with outdoor mobility and the other with reading as their main priority. Conclusion: Further work is needed and caution required in interpreting data obtained using these methodologies for determining their relative importance in vision-related QoL studies.

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Quality of life and relative importance: A comparison of time trade-off and conjoint analysis methods in patients with age-related macular degeneration

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