Abstract
It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.
| Original language | English |
|---|---|
| Pages (from-to) | pe50 |
| Journal | Science Signaling |
| Volume | 5 |
| Issue number | 250 |
| DOIs | |
| Publication status | Published - 13 Nov 2012 |
Keywords
- Animals
- Cell Proliferation
- Exosomes
- Humans
- Neoplasm Proteins
- Neoplasms
- PTEN Phosphohydrolase
- Signal Transduction
