PTEN: an intercellular peacekeeper?

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13 Citations (Scopus)


It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.
Original languageEnglish
Pages (from-to)pe50
JournalScience Signaling
Issue number250
Publication statusPublished - 13 Nov 2012


  • Animals
  • Cell Proliferation
  • Exosomes
  • Humans
  • Neoplasm Proteins
  • Neoplasms
  • PTEN Phosphohydrolase
  • Signal Transduction


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