Abstract
It is generally assumed that cells synthesize their own intracellular enzymes. Therefore, if expression of a specific gene is silenced in a potential cancer cell, it is expected that loss of protein function will follow. A provocative study indicates an unexpected mechanism of intercellular tumor suppression, showing that PTEN (phosphatase and tensin homolog deleted from chromosome 10), a cytosolic enzyme, can be transferred between cells in exosomes to suppress signaling and proliferation in target cells.
Original language | English |
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Pages (from-to) | pe50 |
Journal | Science Signaling |
Volume | 5 |
Issue number | 250 |
DOIs | |
Publication status | Published - 13 Nov 2012 |
Keywords
- Animals
- Cell Proliferation
- Exosomes
- Humans
- Neoplasm Proteins
- Neoplasms
- PTEN Phosphohydrolase
- Signal Transduction