PtdIns(3,4,5)P3-dependent and -independent roles for PTEN in the control of cell migration

Nick R Leslie; Xuesong Yang; C Peter Downes; Cornelis J Weijer

doi:10.1016/j.cub.2006.12.026

PtdIns(3,4,5)P₃-dependent and -independent roles for PTEN in the control of cell migration

Nick R Leslie
, Xuesong Yang
, C Peter Downes
, Cornelis J Weijer

Research output: Contribution to journal › Article › peer-review

152 Citations (Scopus)

Abstract

Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.

Original language	English
Pages (from-to)	115-125
Number of pages	11
Journal	Current Biology
Volume	17
Issue number	2
DOIs	https://doi.org/10.1016/j.cub.2006.12.026
Publication status	Published - 23 Jan 2007

Keywords

Animals
Cell Movement
Chick Embryo
Gastrula
Mesoderm
PTEN Phosphohydrolase
Phosphatidylinositol Phosphates
Protein Structure, Tertiary

Access to Document

10.1016/j.cub.2006.12.026

Cite this

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title = "PtdIns(3,4,5)P3-dependent and -independent roles for PTEN in the control of cell migration",

abstract = "Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.",

keywords = "Animals, Cell Movement, Chick Embryo, Gastrula, Mesoderm, PTEN Phosphohydrolase, Phosphatidylinositol Phosphates, Protein Structure, Tertiary",

author = "Leslie, \{Nick R\} and Xuesong Yang and Downes, \{C Peter\} and Weijer, \{Cornelis J\}",

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AU - Leslie, Nick R

AU - Yang, Xuesong

AU - Downes, C Peter

AU - Weijer, Cornelis J

PY - 2007/1/23

Y1 - 2007/1/23

N2 - Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.

AB - Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.

KW - Animals

KW - Cell Movement

KW - Chick Embryo

KW - Gastrula

KW - Mesoderm

KW - PTEN Phosphohydrolase

KW - Phosphatidylinositol Phosphates

KW - Protein Structure, Tertiary

U2 - 10.1016/j.cub.2006.12.026

DO - 10.1016/j.cub.2006.12.026

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SN - 0960-9822

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EP - 125

JO - Current Biology

JF - Current Biology

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