PtdIns(3,4,5)P3-dependent and -independent roles for PTEN in the control of cell migration

Nick R Leslie, Xuesong Yang, C Peter Downes, Cornelis J Weijer

Research output: Contribution to journalArticlepeer-review

146 Citations (Scopus)


Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.
Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalCurrent Biology
Issue number2
Publication statusPublished - 23 Jan 2007


  • Animals
  • Cell Movement
  • Chick Embryo
  • Gastrula
  • Mesoderm
  • PTEN Phosphohydrolase
  • Phosphatidylinositol Phosphates
  • Protein Structure, Tertiary


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