Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.
- Cell Movement
- Chick Embryo
- PTEN Phosphohydrolase
- Phosphatidylinositol Phosphates
- Protein Structure, Tertiary