PtdIns(3,4,5)P3-dependent and -independent roles for PTEN in the control of cell migration

Nick R Leslie, Xuesong Yang, C Peter Downes, Cornelis J Weijer

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Phosphatase and tensin homolog (PTEN) mediates many of its effects on proliferation, growth, survival, and migration through its PtdIns(3,4,5)P(3) lipid phosphatase activity, suppressing phosphoinositide 3-kinase (PI3K)-dependent signaling pathways. PTEN also possesses a protein phosphatase activity, the role of which is less well characterized.
Original languageEnglish
Pages (from-to)115-125
Number of pages11
JournalCurrent Biology
Volume17
Issue number2
DOIs
Publication statusPublished - 23 Jan 2007

Keywords

  • Animals
  • Cell Movement
  • Chick Embryo
  • Gastrula
  • Mesoderm
  • PTEN Phosphohydrolase
  • Phosphatidylinositol Phosphates
  • Protein Structure, Tertiary

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