Process Input Optimization for Continuous Crystallization of β form L-glutamic acid

Siwei Yang, Haichen Yu, Mingyan Zhao, Tao Liu, Xiongwei Ni

Research output: Chapter in Book/Report/Conference proceedingConference contribution


For using the continuous oscillatory baffled crystallizer (COBC) to conduct cooling crystallization of β form L-glutamic acid (LGA), a prediction model of crystal product size distribution and an optimization method of process operation conditions are proposed in this paper, based on the design of experiment. The oscillation frequency and cooling rates of front two zones of the COBC are taken as the input conditions to design a 3-factor and 3-level Box-Behnken experimental scheme. A prediction model of crystal product size distribution based on double-layer basis functions is constructed by examining the chord length distribution of crystal products under different experimental conditions. Then an objective function on the target crystal size distribution and product yield is introduced to establish an optimization method on the process operating conditions, based on the above prediction model. The effectiveness and advantages of the proposed method are verified by simulation and experiments on the continuous cooling crystallization process of p form LGA.
Original languageEnglish
Title of host publication2022 China Automation Congress (CAC)
Number of pages5
ISBN (Electronic)9781665465335
Publication statusPublished - 13 Mar 2023
Event2022 China Automation Congress - Xiamen, China
Duration: 25 Nov 202227 Nov 2022


Conference2022 China Automation Congress
Abbreviated titleCAC 2022


  • Continuous oscillatory baffled crystallizer
  • Cooling crystallization of L-glutamic acid
  • Design of experiments
  • Prediction model
  • Process Input Optimization
  • crystal size distribution

ASJC Scopus subject areas

  • Renewable Energy, Sustainability and the Environment
  • Aerospace Engineering
  • Control and Systems Engineering
  • Industrial and Manufacturing Engineering
  • Mechanical Engineering
  • Control and Optimization


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