Probing the substrate specificity of the catalytically self-sufficient cytochrome P450RhF from a Rhodococcus sp.

Ayhan Celik; Gareth A. Roberts; John H. White; Stephen K. Chapman; Nicholas J. Turner; Sabine L. Flitsch

doi:10.1039/b609427a

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450RhF from a Rhodococcus sp.

Ayhan Celik, Gareth A. Roberts, John H. White, Stephen K. Chapman, Nicholas J. Turner, Sabine L. Flitsch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl - aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.

Original language	English
Pages (from-to)	4492-4494
Number of pages	3
Journal	Chemical Communications
Issue number	43
DOIs	https://doi.org/10.1039/b609427a
Publication status	Published - 2006

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title = "Probing the substrate specificity of the catalytically self-sufficient cytochrome P450RhF from a Rhodococcus sp.",

abstract = "Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl - aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.",

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author = "Ayhan Celik and Roberts, {Gareth A.} and White, {John H.} and Chapman, {Stephen K.} and Turner, {Nicholas J.} and Flitsch, {Sabine L.}",

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language = "English",

pages = "4492--4494",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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AU - Celik, Ayhan

AU - Roberts, Gareth A.

AU - White, John H.

AU - Chapman, Stephen K.

AU - Turner, Nicholas J.

AU - Flitsch, Sabine L.

PY - 2006

Y1 - 2006

N2 - Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl - aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.

AB - Analysis of the substrate specificity of the self-sufficient cytochrome P450 RhF revealed that the enzyme tends to catalyse the dealkylation of substituted alkyl - aryl ethers with shorter alkyl moieties more readily than equivalent compounds with longer alkyl groups.

KW - DOMAIN

U2 - 10.1039/b609427a

DO - 10.1039/b609427a

M3 - Article

SN - 1359-7345

SP - 4492

EP - 4494

JO - Chemical Communications

JF - Chemical Communications

IS - 43

ER -

Probing the substrate specificity of the catalytically self-sufficient cytochrome P450RhF from a Rhodococcus sp.

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