Primary Amoebic Meningoencephalitis

Ruqaiyyah Siddiqui, Ibne Karim M. Ali, Jennifer R. Cope, Naveed Ahmed Khan

Research output: Book/ReportBook


Since the discovery of N. fowleri several decades ago, major efforts have failed to prevent and successfully treat primary amoebic meningoencephalitis. It is considered as one of the most aggressive parasitic infections, that almost always leads to death within a few days. The clinical course is dramatic exhibiting headache, stiff neck, seizures, coma, and death. The trophozoite enters the nose via contaminated water or dust, travels along the olfactory neuroepithelial route to reach the central nervous system and to provoke haemorrhagic necrosis. With the devastating nature of this disease and problems associated with its chemotherapy, here we describe the clinical features, pathophysiology and risk factors associated with primary amoebic meningoencephalitis.
Original languageEnglish
Place of PublicationNorfolk, UK
PublisherCaister Academic Press
Number of pages11
ISBN (Electronic)9781910190548
ISBN (Print)9781910190531
Publication statusPublished - Jun 2016

Publication series

NameBrain-eating Amoebae: Biology and Pathogenesis of Naegleria fowleri
PublisherCaister Academic Press


  • Amoebida
  • Amœbida
  • Central Nervous System Diseases
  • Central Nervous System Protozoal Infections
  • Central nervous system Diseases
  • Naegleria
  • Naegleria fowleri
  • SCIENCE Life Sciences Biology
  • SCIENCE Life Sciences Microbiology
  • Système nerveux central Maladies


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