Preparation and Characterization of Iron Oxide-Silica Composite Particles Using Mesoporous SBA-15 Silica as Template and Their Internalization Into Mesenchymal Stem Cell and Human Bone Cell Lines

Humphrey Hak Ping Yiu, Martin J Maple, M. R. Lees, Iryna Palona, A. J. El Haj, Jon Dobson

Research output: Contribution to journalArticle

Abstract

A new procedure for preparing iron oxide-silica nanocomposite particles using SBA-15 mesoporous silica as a template is described. These composite materials retained the 2-D hexagonal structure of the SBA-15 template. Transmission electron micrograms of the particles depicted the formation of iron oxide nanocrystals inside the mesochannels of SBA-15 silica framework. Powder x-ray diffraction showed that the iron oxide core of the composite particles consists of a mixture of maghemite (gamma-Fe(2)O(3)) and heamatite (alpha-Fe(2)O(3)), which is the predominant component. Superconducting quantum interference device (SQUID) magnetometry studies showed that these iron oxide-silica composite materials exhibit superparamagnetic properties. On increasing the iron oxide content, the composite particles exhibited a stronger response to magnetic fields but a less homogeneous core, with some large iron oxide particles which were thought to be formed outside the mesochannels of the SBA-15 template. Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed.
Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalIEEE Transactions on NanoBioscience
Volume9
Issue number3
DOIs
Publication statusPublished - 2010

Fingerprint

Stem cells
Silicon Dioxide
Bone
Cells
Composite materials
SQUIDs
Bioelectric potentials
Biotechnology
SBA-15
ferric oxide
Powders
Nanocrystals
Medicine
Nanocomposites
Diffraction
Magnetic fields
X rays
Electrons

Keywords

  • Internalization
  • iron oxide
  • magnetic nanoparticles
  • mescenchymal stem cells
  • mesoporous silica

Cite this

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title = "Preparation and Characterization of Iron Oxide-Silica Composite Particles Using Mesoporous SBA-15 Silica as Template and Their Internalization Into Mesenchymal Stem Cell and Human Bone Cell Lines",
abstract = "A new procedure for preparing iron oxide-silica nanocomposite particles using SBA-15 mesoporous silica as a template is described. These composite materials retained the 2-D hexagonal structure of the SBA-15 template. Transmission electron micrograms of the particles depicted the formation of iron oxide nanocrystals inside the mesochannels of SBA-15 silica framework. Powder x-ray diffraction showed that the iron oxide core of the composite particles consists of a mixture of maghemite (gamma-Fe(2)O(3)) and heamatite (alpha-Fe(2)O(3)), which is the predominant component. Superconducting quantum interference device (SQUID) magnetometry studies showed that these iron oxide-silica composite materials exhibit superparamagnetic properties. On increasing the iron oxide content, the composite particles exhibited a stronger response to magnetic fields but a less homogeneous core, with some large iron oxide particles which were thought to be formed outside the mesochannels of the SBA-15 template. Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed.",
keywords = "Internalization, iron oxide , magnetic nanoparticles , mescenchymal stem cells , mesoporous silica",
author = "Yiu, {Humphrey Hak Ping} and Maple, {Martin J} and Lees, {M. R.} and Iryna Palona and {El Haj}, {A. J.} and Jon Dobson",
year = "2010",
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language = "English",
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T1 - Preparation and Characterization of Iron Oxide-Silica Composite Particles Using Mesoporous SBA-15 Silica as Template and Their Internalization Into Mesenchymal Stem Cell and Human Bone Cell Lines

AU - Yiu, Humphrey Hak Ping

AU - Maple, Martin J

AU - Lees, M. R.

AU - Palona, Iryna

AU - El Haj, A. J.

AU - Dobson, Jon

PY - 2010

Y1 - 2010

N2 - A new procedure for preparing iron oxide-silica nanocomposite particles using SBA-15 mesoporous silica as a template is described. These composite materials retained the 2-D hexagonal structure of the SBA-15 template. Transmission electron micrograms of the particles depicted the formation of iron oxide nanocrystals inside the mesochannels of SBA-15 silica framework. Powder x-ray diffraction showed that the iron oxide core of the composite particles consists of a mixture of maghemite (gamma-Fe(2)O(3)) and heamatite (alpha-Fe(2)O(3)), which is the predominant component. Superconducting quantum interference device (SQUID) magnetometry studies showed that these iron oxide-silica composite materials exhibit superparamagnetic properties. On increasing the iron oxide content, the composite particles exhibited a stronger response to magnetic fields but a less homogeneous core, with some large iron oxide particles which were thought to be formed outside the mesochannels of the SBA-15 template. Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed.

AB - A new procedure for preparing iron oxide-silica nanocomposite particles using SBA-15 mesoporous silica as a template is described. These composite materials retained the 2-D hexagonal structure of the SBA-15 template. Transmission electron micrograms of the particles depicted the formation of iron oxide nanocrystals inside the mesochannels of SBA-15 silica framework. Powder x-ray diffraction showed that the iron oxide core of the composite particles consists of a mixture of maghemite (gamma-Fe(2)O(3)) and heamatite (alpha-Fe(2)O(3)), which is the predominant component. Superconducting quantum interference device (SQUID) magnetometry studies showed that these iron oxide-silica composite materials exhibit superparamagnetic properties. On increasing the iron oxide content, the composite particles exhibited a stronger response to magnetic fields but a less homogeneous core, with some large iron oxide particles which were thought to be formed outside the mesochannels of the SBA-15 template. Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed.

KW - Internalization

KW - iron oxide

KW - magnetic nanoparticles

KW - mescenchymal stem cells

KW - mesoporous silica

U2 - 10.1109/TNB.2010.2053770

DO - 10.1109/TNB.2010.2053770

M3 - Article

VL - 9

SP - 165

EP - 170

JO - IEEE Transactions on NanoBioscience

JF - IEEE Transactions on NanoBioscience

SN - 1536-1241

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ER -