Preparation and Characterization of Iron Oxide-Silica Composite Particles Using Mesoporous SBA-15 Silica as Template and Their Internalization Into Mesenchymal Stem Cell and Human Bone Cell Lines

Humphrey Hak Ping Yiu, Martin J Maple, M. R. Lees, Iryna Palona, A. J. El Haj, Jon Dobson

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


A new procedure for preparing iron oxide-silica nanocomposite particles using SBA-15 mesoporous silica as a template is described. These composite materials retained the 2-D hexagonal structure of the SBA-15 template. Transmission electron micrograms of the particles depicted the formation of iron oxide nanocrystals inside the mesochannels of SBA-15 silica framework. Powder x-ray diffraction showed that the iron oxide core of the composite particles consists of a mixture of maghemite (gamma-Fe(2)O(3)) and heamatite (alpha-Fe(2)O(3)), which is the predominant component. Superconducting quantum interference device (SQUID) magnetometry studies showed that these iron oxide-silica composite materials exhibit superparamagnetic properties. On increasing the iron oxide content, the composite particles exhibited a stronger response to magnetic fields but a less homogeneous core, with some large iron oxide particles which were thought to be formed outside the mesochannels of the SBA-15 template. Internalization of these particles into human cell lines (mesenchymal stem cells and human bone cells), which indicates their potential in medicine and biotechnology, is also discussed.
Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalIEEE Transactions on NanoBioscience
Issue number3
Publication statusPublished - 2010


  • Internalization
  • iron oxide
  • magnetic nanoparticles
  • mescenchymal stem cells
  • mesoporous silica

Cite this