Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses

Syam M. P. C. Mohanan, Rainer J. Beck, Nicholas P. West, Michael Shires, Sarah L. Perry, David G. Jayne, Duncan P. Hand, Jonathan D. Shephard

Research output: Contribution to journalArticle

Abstract

Ultrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasive or endoscopic procedures has been hindered by the lack of suitable optical fibres for high peak powers. However, recent developments of hollow core microstructured fibres provide potential for delivery of such pulses throughout the body. In this study, analysis of laser ablation via a scanning galvanometer on a porcine colon tissue model is presented. A thermally damaged region (<85 μm) and fine depth control of ablation using the pulse energies 46 and 33 μJ are demonstrated. It is further demonstrated that such pulses suitable for precision porcine colon resection can be flexibly delivered via a hollow core negative curvature fibre (HC-NCF) and again ablation depth can be controlled with a thermally damaged region <85 μm. Ablation volumes are comparable to that of early stage lesions in the inner lining of the colon. This study concludes that the combination of ultrashort pulses and flexible fibre delivery via HC-NCF present a viable route to new minimally invasive surgical procedures.

Original languageEnglish
Article numbere201900055
JournalJournal of Biophotonics
Volume12
Issue number11
Early online date26 Jun 2019
DOIs
Publication statusPublished - Nov 2019

Fingerprint

Ultrafast lasers
Fiber lasers
Laser pulses
hollow
Colon
Lasers
Swine
Ablation
curvature
fibers
Fibers
evaluation
ablation
Tissue
pulses
lasers
Optical Fibers
Minimally Invasive Surgical Procedures
Laser Therapy
Galvanometers

Keywords

  • negative curvature fibre
  • plasma-mediated ablation
  • porcine colon
  • thermal necrosis
  • ultrafast laser surgery

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Physics and Astronomy(all)

Cite this

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title = "Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses",
abstract = "Ultrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasive or endoscopic procedures has been hindered by the lack of suitable optical fibres for high peak powers. However, recent developments of hollow core microstructured fibres provide potential for delivery of such pulses throughout the body. In this study, analysis of laser ablation via a scanning galvanometer on a porcine colon tissue model is presented. A thermally damaged region (<85 μm) and fine depth control of ablation using the pulse energies 46 and 33 μJ are demonstrated. It is further demonstrated that such pulses suitable for precision porcine colon resection can be flexibly delivered via a hollow core negative curvature fibre (HC-NCF) and again ablation depth can be controlled with a thermally damaged region <85 μm. Ablation volumes are comparable to that of early stage lesions in the inner lining of the colon. This study concludes that the combination of ultrashort pulses and flexible fibre delivery via HC-NCF present a viable route to new minimally invasive surgical procedures.",
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Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses. / Mohanan, Syam M. P. C.; Beck, Rainer J.; West, Nicholas P.; Shires, Michael; Perry, Sarah L.; Jayne, David G.; Hand, Duncan P.; Shephard, Jonathan D.

In: Journal of Biophotonics, Vol. 12, No. 11, e201900055, 11.2019.

Research output: Contribution to journalArticle

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AU - Jayne, David G.

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AU - Shephard, Jonathan D.

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