Precision resection of lung cancer in a sheep model using ultrashort laser pulses

Rainer J. Beck, Syam Mohan P. C. Mohanan, Wojciech Stanisław Góra, Chris Cousens, Jeanie Finlayson, Mark P. Dagleish, David J. Griffiths, Jonathan D. Shephard

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent developments and progress in the delivery of high average power ultrafast laser pulses enable a range of novel minimally invasive surgical procedures. Lung cancer is the leading cause of cancer deaths worldwide and here the resection of lung tumours by means of picosecond laser pulses is presented. This represents a potential alternative to mitigate limitations of existing surgical treatments in terms of precision and collateral thermal damage to the healthy tissue. Robust process parameters for the laser resection are demonstrated using ovine pulmonary adenocarcinoma (OPA). OPA is a naturally occurring lung cancer of sheep caused by retrovirus infection that has several features in common with some forms of human pulmonary adenocarcinoma, including a similar histological appearance, which makes it ideally suited for this study. The picosecond laser was operated at a wavelength of 515 nm to resect square cavities from fresh ex-vivo OPA samples using a range of scanning strategies. Process parameters are presented for efficient ablation of the tumour with clear margins and only minimal collateral damage to the surrounding tissue. The resection depth can be controlled precisely by means of the pulse energy. By adjusting the overlap between successive laser pulses, deliberate heat transfer to the tissue and thermal damage can be achieved. This can be beneficial for on demand haemostasis and laser coagulation. Overall, the application of ultrafast lasers for the resection of lung tumours has potential to enable significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional techniques.

LanguageEnglish
Title of host publicationFrontiers in Ultrafast Optics
Subtitle of host publicationBiomedical, Scientific, and Industrial Applications XVII
PublisherSPIE
ISBN (Electronic)9781510606296
DOIs
Publication statusPublished - 17 Feb 2017
EventFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017 - The Moscone Center, San Francisco, United States
Duration: 29 Jan 20172 Feb 2017
Conference number: 10522
https://spie.org/PWL/conferencedetails/frontiers-ultrafast-optics?SSO=1 (Conference website)

Publication series

NameProceedings of SPIE
PublisherSPIE
Volume10094
ISSN (Electronic)1996-756X

Conference

ConferenceFrontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017
CountryUnited States
CitySan Francisco
Period29/01/172/02/17
Internet address

Fingerprint

sheep
Ultrashort Laser Pulses
Lung Cancer
Ultrashort pulses
lungs
Laser pulses
cancer
Tissue
Laser
Tumors
Ultrafast lasers
Damage
Ultrafast Lasers
Tumor
pulses
lasers
Lasers
Process Parameters
Lung
damage

Keywords

  • Large animal model
  • Lung cancer
  • Ovine pulmonary adenocarcinoma
  • Plasma mediated ablation
  • Ultrafast laser surgery

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Beck, R. J., Mohanan, S. M. P. C., Góra, W. S., Cousens, C., Finlayson, J., Dagleish, M. P., ... Shephard, J. D. (2017). Precision resection of lung cancer in a sheep model using ultrashort laser pulses. In Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII [1009405] (Proceedings of SPIE; Vol. 10094). SPIE. https://doi.org/10.1117/12.2252215
Beck, Rainer J. ; Mohanan, Syam Mohan P. C. ; Góra, Wojciech Stanisław ; Cousens, Chris ; Finlayson, Jeanie ; Dagleish, Mark P. ; Griffiths, David J. ; Shephard, Jonathan D. / Precision resection of lung cancer in a sheep model using ultrashort laser pulses. Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII. SPIE, 2017. (Proceedings of SPIE).
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abstract = "Recent developments and progress in the delivery of high average power ultrafast laser pulses enable a range of novel minimally invasive surgical procedures. Lung cancer is the leading cause of cancer deaths worldwide and here the resection of lung tumours by means of picosecond laser pulses is presented. This represents a potential alternative to mitigate limitations of existing surgical treatments in terms of precision and collateral thermal damage to the healthy tissue. Robust process parameters for the laser resection are demonstrated using ovine pulmonary adenocarcinoma (OPA). OPA is a naturally occurring lung cancer of sheep caused by retrovirus infection that has several features in common with some forms of human pulmonary adenocarcinoma, including a similar histological appearance, which makes it ideally suited for this study. The picosecond laser was operated at a wavelength of 515 nm to resect square cavities from fresh ex-vivo OPA samples using a range of scanning strategies. Process parameters are presented for efficient ablation of the tumour with clear margins and only minimal collateral damage to the surrounding tissue. The resection depth can be controlled precisely by means of the pulse energy. By adjusting the overlap between successive laser pulses, deliberate heat transfer to the tissue and thermal damage can be achieved. This can be beneficial for on demand haemostasis and laser coagulation. Overall, the application of ultrafast lasers for the resection of lung tumours has potential to enable significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional techniques.",
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Beck, RJ, Mohanan, SMPC, Góra, WS, Cousens, C, Finlayson, J, Dagleish, MP, Griffiths, DJ & Shephard, JD 2017, Precision resection of lung cancer in a sheep model using ultrashort laser pulses. in Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII., 1009405, Proceedings of SPIE, vol. 10094, SPIE, Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII 2017, San Francisco, United States, 29/01/17. https://doi.org/10.1117/12.2252215

Precision resection of lung cancer in a sheep model using ultrashort laser pulses. / Beck, Rainer J.; Mohanan, Syam Mohan P. C.; Góra, Wojciech Stanisław; Cousens, Chris; Finlayson, Jeanie; Dagleish, Mark P.; Griffiths, David J.; Shephard, Jonathan D.

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII. SPIE, 2017. 1009405 (Proceedings of SPIE; Vol. 10094).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Mohanan, Syam Mohan P. C.

AU - Góra, Wojciech Stanisław

AU - Cousens, Chris

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AB - Recent developments and progress in the delivery of high average power ultrafast laser pulses enable a range of novel minimally invasive surgical procedures. Lung cancer is the leading cause of cancer deaths worldwide and here the resection of lung tumours by means of picosecond laser pulses is presented. This represents a potential alternative to mitigate limitations of existing surgical treatments in terms of precision and collateral thermal damage to the healthy tissue. Robust process parameters for the laser resection are demonstrated using ovine pulmonary adenocarcinoma (OPA). OPA is a naturally occurring lung cancer of sheep caused by retrovirus infection that has several features in common with some forms of human pulmonary adenocarcinoma, including a similar histological appearance, which makes it ideally suited for this study. The picosecond laser was operated at a wavelength of 515 nm to resect square cavities from fresh ex-vivo OPA samples using a range of scanning strategies. Process parameters are presented for efficient ablation of the tumour with clear margins and only minimal collateral damage to the surrounding tissue. The resection depth can be controlled precisely by means of the pulse energy. By adjusting the overlap between successive laser pulses, deliberate heat transfer to the tissue and thermal damage can be achieved. This can be beneficial for on demand haemostasis and laser coagulation. Overall, the application of ultrafast lasers for the resection of lung tumours has potential to enable significantly improved precision and reduced thermal damage to the surrounding tissue compared to conventional techniques.

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M3 - Conference contribution

T3 - Proceedings of SPIE

BT - Frontiers in Ultrafast Optics

PB - SPIE

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Beck RJ, Mohanan SMPC, Góra WS, Cousens C, Finlayson J, Dagleish MP et al. Precision resection of lung cancer in a sheep model using ultrashort laser pulses. In Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XVII. SPIE. 2017. 1009405. (Proceedings of SPIE). https://doi.org/10.1117/12.2252215