In the fabrication of osteochondral tissue engineering scaffolds, the two distinct tissues impose different requirements on the architecture. Stereo-lithography is a rapid prototyping method that can be utilised to make 3D constructs with high spatial control by radical photo-polymerisation. In this study, biodegradable resins are developed that can be applied in stereo-lithography. Photo-crosslinked poly(lactide) networks with varying physical properties were synthesised, and by photo-polymerising in the presence of leachable particles porous scaffolds could be prepared as well.
ASJC Scopus subject areas
- Pharmaceutical Science
Melchels, F. P., Grijpma, D. W., & Feijen, J. (2006). Photo-crosslinking of functionalised lactide oligomers for the fabrication of osteochondral tissue engineering scaffolds. Journal of Controlled Release, 116(2), e98-e100. https://doi.org/10.1016/j.jconrel.2006.09.070