PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

N M HOWARTH, G COOPER, A PUROHIT, L DUNCAN, M J REED, B V L POTTER

Research output: Contribution to journalArticle

Abstract

Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number2
Publication statusPublished - Feb 1993

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