PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

N M  HOWARTH; G  COOPER; A  PUROHIT; L  DUNCAN; M J  REED; B V L  POTTER

PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

N M HOWARTH, G COOPER, A PUROHIT, L DUNCAN, M J REED, B V L POTTER

Research output: Contribution to journal › Article › peer-review

Abstract

Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

Original language	English
Pages (from-to)	313-318
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	2
Publication status	Published - Feb 1993

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title = "PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE",

abstract = "Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.",

author = "HOWARTH, {N M} and G COOPER and A PUROHIT and L DUNCAN and REED, {M J} and POTTER, {B V L}",

year = "1993",

month = feb,

language = "English",

volume = "3",

pages = "313--318",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier",

number = "2",

}

TY - JOUR

T1 - PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

AU - HOWARTH, N M

AU - COOPER, G

AU - PUROHIT, A

AU - DUNCAN, L

AU - REED, M J

AU - POTTER, B V L

PY - 1993/2

Y1 - 1993/2

N2 - Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

AB - Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

M3 - Article

SN - 0960-894X

VL - 3

SP - 313

EP - 318

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 2

ER -

PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

Abstract

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