PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

N M HOWARTH, G COOPER, A PUROHIT, L DUNCAN, M J REED, B V L POTTER

Research output: Contribution to journalArticle

Abstract

Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

Original languageEnglish
Pages (from-to)313-318
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number2
Publication statusPublished - Feb 1993

Cite this

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title = "PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE",
abstract = "Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.",
author = "HOWARTH, {N M} and G COOPER and A PUROHIT and L DUNCAN and REED, {M J} and POTTER, {B V L}",
year = "1993",
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language = "English",
volume = "3",
pages = "313--318",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "2",

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PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE. / HOWARTH, N M ; COOPER, G ; PUROHIT, A ; DUNCAN, L ; REED, M J ; POTTER, B V L .

In: Bioorganic and Medicinal Chemistry Letters, Vol. 3, No. 2, 02.1993, p. 313-318.

Research output: Contribution to journalArticle

TY - JOUR

T1 - PHOSPHONATES AND THIOPHOSPHONATES AS SULFATE SURROGATES - SYNTHESIS OF ESTRONE 3-METHYLTHIOPHOSPHONATE, A POTENT INHIBITOR OF ESTRONE SULFATASE

AU - HOWARTH, N M

AU - COOPER, G

AU - PUROHIT, A

AU - DUNCAN, L

AU - REED, M J

AU - POTTER, B V L

PY - 1993/2

Y1 - 1993/2

N2 - Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

AB - Estrone 3-phosphonates and thiophosphonates have been synthesised as analogues of estrone 3-sulfate and exhibit potent activity as competitive inhibitors of estrone sulfatase, a potential therapeutic target in treatment of breast cancer.

M3 - Article

VL - 3

SP - 313

EP - 318

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 2

ER -