Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Pier-Francesco Caponi; Xing-Ping Qiu; Filipe Vilela; Francoise M Winnik; Rein V Ulijn

doi:10.1039/c0py00291g

Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Pier-Francesco Caponi, Xing-Ping Qiu, Filipe Vilela, Francoise M Winnik, Rein V Ulijn

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.

Original language	English
Pages (from-to)	306-308
Number of pages	3
Journal	Polymer Chemistry
Issue number	2
DOIs	https://doi.org/10.1039/c0py00291g
Publication status	Published - 1 Feb 2011

Keywords

HYDROGELS
POLYMERS
POLY(2-OXAZOLINE)S
POLYMERIZATION
COPOLYMERS
LIPOSOMES
PROTEINS
RELEASE
CELLS

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10.1039/c0py00291g

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title = "Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)",

abstract = "We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.",

keywords = "HYDROGELS, POLYMERS, POLY(2-OXAZOLINE)S, POLYMERIZATION, COPOLYMERS, LIPOSOMES, PROTEINS, RELEASE, CELLS",

author = "Pier-Francesco Caponi and Xing-Ping Qiu and Filipe Vilela and Winnik, {Francoise M} and Ulijn, {Rein V}",

year = "2011",

month = feb,

day = "1",

doi = "10.1039/c0py00291g",

language = "English",

pages = "306--308",

journal = "Polymer Chemistry",

issn = "1759-9954",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

AU - Caponi, Pier-Francesco

AU - Qiu, Xing-Ping

AU - Vilela, Filipe

AU - Winnik, Francoise M

AU - Ulijn, Rein V

PY - 2011/2/1

Y1 - 2011/2/1

N2 - We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.

AB - We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.

KW - HYDROGELS

KW - POLYMERS

KW - POLY(2-OXAZOLINE)S

KW - POLYMERIZATION

KW - COPOLYMERS

KW - LIPOSOMES

KW - PROTEINS

KW - RELEASE

KW - CELLS

U2 - 10.1039/c0py00291g

DO - 10.1039/c0py00291g

M3 - Article

SN - 1759-9954

SP - 306

EP - 308

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 2

ER -

Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Abstract

Keywords

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