Phosphatase/temperature responsive poly(2-isopropyl-2-oxazoline)

Pier-Francesco Caponi, Xing-Ping Qiu, Filipe Vilela, Francoise M Winnik, Rein V Ulijn

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We demonstrate a strategy for producing polymer bioconjugates which display both enzymatic and thermal responsiveness. This is achieved by combining the thermo-responsive properties of poly(2-isopropyl-2-oxazoline) (PiPrOx) with the self-assembly properties of fluorenylmethoxycarbonyl-tyrosine (Fmoc-Y), controlled by a phosphatase triggered mechanism.

Original languageEnglish
Pages (from-to)306-308
Number of pages3
JournalPolymer Chemistry
Issue number2
DOIs
Publication statusPublished - 1 Feb 2011

Keywords

  • HYDROGELS
  • POLYMERS
  • POLY(2-OXAZOLINE)S
  • POLYMERIZATION
  • COPOLYMERS
  • LIPOSOMES
  • PROTEINS
  • RELEASE
  • CELLS

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