Abstract
The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 µg kg-1 and 250 µg kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed rapidly. The elimination half-life was 186 min.
| Original language | English |
|---|---|
| Pages (from-to) | 27-30 |
| Number of pages | 4 |
| Journal | British Journal of Anaesthesia |
| Volume | 53 |
| Issue number | 1 |
| Publication status | Published - 1981 |