Pharmacokinetics and analgesic effects of ketamine in man

J A Clements, W S Nimmo

    Research output: Contribution to journalArticlepeer-review

    259 Citations (Scopus)


    The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 µg kg-1 and 250 µg kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed rapidly. The elimination half-life was 186 min.

    Original languageEnglish
    Pages (from-to)27-30
    Number of pages4
    JournalBritish Journal of Anaesthesia
    Issue number1
    Publication statusPublished - 1981


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