The pharmacokinetics and analgesic effect of i.v. ketamine in doses of 125 µg kg-1 and 250 µg kg-1 were determined in five healthy volunteers. Analgesia was measured with the submaximal effort tourniquet test. Both doses of ketamine prolonged the period of pain-free ischemic exercise while the plasma ketamine concentration was greater than 100 ng ml-1. Ketamine was distributed rapidly. The elimination half-life was 186 min.
|Number of pages
|British Journal of Anaesthesia
|Published - 1981