pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays

Katjana Ehrlich; A. Kufcsák; Sarah McAughtrie; H. Fleming; N. Krstajic; C. J. Campbell; R. K. Henderson; K. Dhaliwal; Robert R. Thomson; Michael George Tanner

doi:10.1364/OE.25.030976

pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays

Katjana Ehrlich, A. Kufcsák, Sarah McAughtrie, H. Fleming, N. Krstajic, C. J. Campbell, R. K. Henderson, K. Dhaliwal, Robert R. Thomson, Michael George Tanner

School of Engineering & Physical Sciences

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Abstract

Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement. In this manner, pH sensing through a multimode fibre at a low excitation power that is safe for future in vivo applications, with short acquisition times (10 or 60 s), is demonstrated. A measurement precision of ± 0.07 pH units is thus achieved.

Original language	English
Pages (from-to)	30976-30986
Number of pages	11
Journal	Optics Express
Volume	25
Issue number	25
Early online date	27 Nov 2017
DOIs	https://doi.org/10.1364/OE.25.030976
Publication status	Published - 11 Dec 2017

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title = "pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays",

abstract = "Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement. In this manner, pH sensing through a multimode fibre at a low excitation power that is safe for future in vivo applications, with short acquisition times (10 or 60 s), is demonstrated. A measurement precision of ± 0.07 pH units is thus achieved.",

author = "Katjana Ehrlich and A. Kufcs{\'a}k and Sarah McAughtrie and H. Fleming and N. Krstajic and Campbell, {C. J.} and Henderson, {R. K.} and K. Dhaliwal and Thomson, {Robert R.} and Tanner, {Michael George}",

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AU - Ehrlich, Katjana

AU - Kufcsák, A.

AU - McAughtrie, Sarah

AU - Fleming, H.

AU - Krstajic, N.

AU - Campbell, C. J.

AU - Henderson, R. K.

AU - Dhaliwal, K.

AU - Thomson, Robert R.

AU - Tanner, Michael George

PY - 2017/12/11

Y1 - 2017/12/11

N2 - Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement. In this manner, pH sensing through a multimode fibre at a low excitation power that is safe for future in vivo applications, with short acquisition times (10 or 60 s), is demonstrated. A measurement precision of ± 0.07 pH units is thus achieved.

AB - Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement. In this manner, pH sensing through a multimode fibre at a low excitation power that is safe for future in vivo applications, with short acquisition times (10 or 60 s), is demonstrated. A measurement precision of ± 0.07 pH units is thus achieved.

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JO - Optics Express

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pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays

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