pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays

Katjana Ehrlich, A. Kufcsák, Sarah McAughtrie, H. Fleming, N. Krstajic, C. J. Campbell, R. K. Henderson, K. Dhaliwal, Robert R. Thomson, Michael George Tanner

Research output: Contribution to journalArticle

Abstract

Full exploitation of fibre Raman probes has been limited by the obstruction of weak Raman signals by background fluorescence of the sample and the intrinsic Raman signal of the delivery fibre. Here we utilised functionalised gold nanoshells (NS) to take advantage of the surface-enhanced Raman spectroscopy (SERS) effect to enhance the pH responsive spectrum of 4-mercaptobenzoic acid (MBA). However, the fibre background is still dominant. Using the photon arrival time-resolving capability of a CMOS single-photon avalanche diode (SPAD) based line sensor, we recover the SERS spectrum without a fibre background in a 10 s measurement. In this manner, pH sensing through a multimode fibre at a low excitation power that is safe for future in vivo applications, with short acquisition times (10 or 60 s), is demonstrated. A measurement precision of ± 0.07 pH units is thus achieved.
Original languageEnglish
Pages (from-to)30976-30986
Number of pages11
JournalOptics Express
Volume25
Issue number25
Early online date27 Nov 2017
DOIs
Publication statusPublished - 11 Dec 2017

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Avalanches
Optical Fibers
Raman Spectrum Analysis
Photons
Nanoshells
Gold
Fluorescence

Cite this

Ehrlich, K., Kufcsák, A., McAughtrie, S., Fleming, H., Krstajic, N., Campbell, C. J., ... Tanner, M. G. (2017). pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays. Optics Express, 25(25), 30976-30986. https://doi.org/10.1364/OE.25.030976
Ehrlich, Katjana ; Kufcsák, A. ; McAughtrie, Sarah ; Fleming, H. ; Krstajic, N. ; Campbell, C. J. ; Henderson, R. K. ; Dhaliwal, K. ; Thomson, Robert R. ; Tanner, Michael George. / pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays. In: Optics Express. 2017 ; Vol. 25, No. 25. pp. 30976-30986.
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Ehrlich, K, Kufcsák, A, McAughtrie, S, Fleming, H, Krstajic, N, Campbell, CJ, Henderson, RK, Dhaliwal, K, Thomson, RR & Tanner, MG 2017, 'pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays', Optics Express, vol. 25, no. 25, pp. 30976-30986. https://doi.org/10.1364/OE.25.030976

pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays. / Ehrlich, Katjana; Kufcsák, A.; McAughtrie, Sarah; Fleming, H.; Krstajic, N.; Campbell, C. J.; Henderson, R. K.; Dhaliwal, K.; Thomson, Robert R.; Tanner, Michael George.

In: Optics Express, Vol. 25, No. 25, 11.12.2017, p. 30976-30986.

Research output: Contribution to journalArticle

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AU - Ehrlich, Katjana

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AU - McAughtrie, Sarah

AU - Fleming, H.

AU - Krstajic, N.

AU - Campbell, C. J.

AU - Henderson, R. K.

AU - Dhaliwal, K.

AU - Thomson, Robert R.

AU - Tanner, Michael George

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Ehrlich K, Kufcsák A, McAughtrie S, Fleming H, Krstajic N, Campbell CJ et al. pH sensing through a single optical fibre using SERS and CMOS SPAD line arrays. Optics Express. 2017 Dec 11;25(25):30976-30986. https://doi.org/10.1364/OE.25.030976