PepTherDia: database and structural composition analysis of approved peptide therapeutics and diagnostics

Vera D'Aloisio, Paolo Dognini, Gillian A. Hutcheon, Christopher R. Coxon

Research output: Contribution to journalReview articlepeer-review

Abstract

As of 2020, there were >100 approved peptides with therapeutic or diagnostic applications. However, a complete database providing information on marketed peptides is not freely available, making the peptide chemists’ job of designing future peptide drug candidates challenging. Unlike the rules for small-molecule drugs, there is no general set of guidelines for designing a successful peptide-based drug. In this review, together with our freely available database (PepTherDia, http://peptherdia.herokuapp.com), we provide insights into what a successful peptide therapeutic or diagnostic agent looks like and lay the foundation for establishing a set of rules to help future medicinal chemists to design peptide candidates with increased approval rates. We describe a freely accessible database of approved peptide therapeutics and diagnostics, providing an overview of key structural and compositional trends to help guide the design of future peptide medicines.

Original languageEnglish
JournalDrug Discovery Today
Early online date26 Feb 2021
DOIs
Publication statusE-pub ahead of print - 26 Feb 2021

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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