PepTherDia: database and structural composition analysis of approved peptide therapeutics and diagnostics

Vera D'Aloisio, Paolo Dognini, Gillian A. Hutcheon, Christopher R. Coxon

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

As of 2020, there were >100 approved peptides with therapeutic or diagnostic applications. However, a complete database providing information on marketed peptides is not freely available, making the peptide chemists’ job of designing future peptide drug candidates challenging. Unlike the rules for small-molecule drugs, there is no general set of guidelines for designing a successful peptide-based drug. In this review, together with our freely available database (PepTherDia, http://peptherdia.herokuapp.com), we provide insights into what a successful peptide therapeutic or diagnostic agent looks like and lay the foundation for establishing a set of rules to help future medicinal chemists to design peptide candidates with increased approval rates.

Original languageEnglish
Pages (from-to)1409-1419
Number of pages11
JournalDrug Discovery Today
Volume26
Issue number6
Early online date26 Feb 2021
DOIs
Publication statusPublished - Jun 2021

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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