TY - JOUR
T1 - PepTherDia
T2 - database and structural composition analysis of approved peptide therapeutics and diagnostics
AU - D'Aloisio, Vera
AU - Dognini, Paolo
AU - Hutcheon, Gillian A.
AU - Coxon, Christopher R.
N1 - Funding Information:
The authors gratefully acknowledge Daniele Tomasi for the development of the website PepTherDia. This work was supported by a Liverpool John Moores University Vice Chancellor’s PhD Scholarship (V.D’A.) and a University Alliance Doctoral Training Alliance COFUND/Marie Skłodowska-Curie (European Union’s Horizon 2020 research and innovation programme, grant agreement No 801604) PhD Fellowship Programme in Applied Biosciences for Health (P.D.). The funding sources had no involvement in the study design.
Publisher Copyright:
© 2021 Elsevier Ltd
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - As of 2020, there were >100 approved peptides with therapeutic or diagnostic applications. However, a complete database providing information on marketed peptides is not freely available, making the peptide chemists’ job of designing future peptide drug candidates challenging. Unlike the rules for small-molecule drugs, there is no general set of guidelines for designing a successful peptide-based drug. In this review, together with our freely available database (PepTherDia, http://peptherdia.herokuapp.com), we provide insights into what a successful peptide therapeutic or diagnostic agent looks like and lay the foundation for establishing a set of rules to help future medicinal chemists to design peptide candidates with increased approval rates.
AB - As of 2020, there were >100 approved peptides with therapeutic or diagnostic applications. However, a complete database providing information on marketed peptides is not freely available, making the peptide chemists’ job of designing future peptide drug candidates challenging. Unlike the rules for small-molecule drugs, there is no general set of guidelines for designing a successful peptide-based drug. In this review, together with our freely available database (PepTherDia, http://peptherdia.herokuapp.com), we provide insights into what a successful peptide therapeutic or diagnostic agent looks like and lay the foundation for establishing a set of rules to help future medicinal chemists to design peptide candidates with increased approval rates.
UR - http://www.scopus.com/inward/record.url?scp=85102102198&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2021.02.019
DO - 10.1016/j.drudis.2021.02.019
M3 - Review article
C2 - 33647438
SN - 1359-6446
VL - 26
SP - 1409
EP - 1419
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 6
ER -