Patterning of microspheres and microbubbles in an acoustic tweezers

A. L. Bernassau, P. G. A. MacPherson, J. Beeley, B. W. Drinkwater, D. R. S. Cumming

Research output: Contribution to journalArticle

20 Citations (Scopus)
109 Downloads (Pure)

Abstract

We describe the construction of an ultrasonic device capable of micro-patterning a range of microscopic particles for bioengineering applications such as targeted drug delivery. The device is formed from seven ultrasonic transducers positioned around a heptagonal cavity. By exciting two or three transducers simultaneously, lines or hexagonal shapes can be formed with microspheres, emulsions and microbubbles. Furthermore, phase control of the transducers allows patterning at any desired position in a controlled manner. The paper discusses in detail direct positioning of functionalised microspheres, emulsions and microbubbles. With the advantages of miniaturization, rapid and simple fabrication, ultrasonic tweezers is a potentially useful tool in many biomedical applications.

Original languageEnglish
Pages (from-to)289-297
Number of pages9
JournalBiomedical Microdevices
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Acoustic radiation pressure
  • Particle patterning
  • 2D particle manipulation
  • Sonotweezers
  • ULTRASONIC STANDING WAVES
  • MAMMALIAN-CELLS
  • CONTRAST AGENTS
  • DRUG-DELIVERY
  • MANIPULATION
  • PARTICLES
  • DIELECTROPHORESIS
  • LIPOSOMES
  • SEPARATION
  • SCALE

Cite this

Bernassau, A. L., MacPherson, P. G. A., Beeley, J., Drinkwater, B. W., & Cumming, D. R. S. (2013). Patterning of microspheres and microbubbles in an acoustic tweezers. Biomedical Microdevices, 15(2), 289-297. https://doi.org/10.1007/s10544-012-9729-5