Patterning of microspheres and microbubbles in an acoustic tweezers

A. L. Bernassau; P. G. A. MacPherson; J. Beeley; B. W. Drinkwater; D. R. S. Cumming

doi:10.1007/s10544-012-9729-5

Patterning of microspheres and microbubbles in an acoustic tweezers

A. L. Bernassau^*, P. G. A. MacPherson, J. Beeley, B. W. Drinkwater, D. R. S. Cumming

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

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Abstract

We describe the construction of an ultrasonic device capable of micro-patterning a range of microscopic particles for bioengineering applications such as targeted drug delivery. The device is formed from seven ultrasonic transducers positioned around a heptagonal cavity. By exciting two or three transducers simultaneously, lines or hexagonal shapes can be formed with microspheres, emulsions and microbubbles. Furthermore, phase control of the transducers allows patterning at any desired position in a controlled manner. The paper discusses in detail direct positioning of functionalised microspheres, emulsions and microbubbles. With the advantages of miniaturization, rapid and simple fabrication, ultrasonic tweezers is a potentially useful tool in many biomedical applications.

Original language	English
Pages (from-to)	289-297
Number of pages	9
Journal	Biomedical Microdevices
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s10544-012-9729-5
Publication status	Published - Apr 2013

Keywords

Acoustic radiation pressure
Particle patterning
2D particle manipulation
Sonotweezers
ULTRASONIC STANDING WAVES
MAMMALIAN-CELLS
CONTRAST AGENTS
DRUG-DELIVERY
MANIPULATION
PARTICLES
DIELECTROPHORESIS
LIPOSOMES
SEPARATION
SCALE

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Cite this

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title = "Patterning of microspheres and microbubbles in an acoustic tweezers",

abstract = "We describe the construction of an ultrasonic device capable of micro-patterning a range of microscopic particles for bioengineering applications such as targeted drug delivery. The device is formed from seven ultrasonic transducers positioned around a heptagonal cavity. By exciting two or three transducers simultaneously, lines or hexagonal shapes can be formed with microspheres, emulsions and microbubbles. Furthermore, phase control of the transducers allows patterning at any desired position in a controlled manner. The paper discusses in detail direct positioning of functionalised microspheres, emulsions and microbubbles. With the advantages of miniaturization, rapid and simple fabrication, ultrasonic tweezers is a potentially useful tool in many biomedical applications.",

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author = "Bernassau, {A. L.} and MacPherson, {P. G. A.} and J. Beeley and Drinkwater, {B. W.} and Cumming, {D. R. S.}",

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AU - Bernassau, A. L.

AU - MacPherson, P. G. A.

AU - Beeley, J.

AU - Drinkwater, B. W.

AU - Cumming, D. R. S.

PY - 2013/4

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KW - Acoustic radiation pressure

KW - Particle patterning

KW - 2D particle manipulation

KW - Sonotweezers

KW - ULTRASONIC STANDING WAVES

KW - MAMMALIAN-CELLS

KW - CONTRAST AGENTS

KW - DRUG-DELIVERY

KW - MANIPULATION

KW - PARTICLES

KW - DIELECTROPHORESIS

KW - LIPOSOMES

KW - SEPARATION

KW - SCALE

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EP - 297

JO - Biomedical Microdevices

JF - Biomedical Microdevices

IS - 2

ER -

Patterning of microspheres and microbubbles in an acoustic tweezers

Abstract

Keywords

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