Parametrical modeling and design optimization of blood plasma separation device with microchannel mechanism

Xiangdong Xue, Mayur K. Patel, Maïwenn Kersaudy-Kerhoas, Chris Bailey, Marc P. Y. Desmulliez, Maïwenn Kersaudy-Kerhoas

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

This paper presents an analysis of biofluid behavior in a T-shaped microchannel device and a design optimization for improved biofluid performance in terms of particle liquid separation. The biofluid is modeled with single phase shear rate non-Newtonian flow with blood property. The separation of red blood cell from plasma is evident based on biofluid distribution in the microchannels against various relevant effects and findings, including Zweifach-Fung bifurcation law, Fahraeus effect, Fahraeus-Lindqvist effect and cell-free phenomenon. The modeling with the initial device shows that this T-microchannel device can separate red blood cell from plasma but the separation efficiency among different bifurcations varies largely. In accordance with the imbalanced performance, a design optimization is conducted. This includes implementing a series of simulations to investigate the effect of the lengths of the main and branch channels to biofluid behavior and searching an improved design with optimal separation performance. It is found that changing relative lengths of branch channels is effective to both uniformity of flow rate ratio among bifurcations and reduction of difference of the flow velocities between the branch channels, whereas extending the length of the main channel from bifurcation region is only effective foruniformity of flow rate ratio. © 2009 IEEE.

Original languageEnglish
Title of host publication2009 IEEE 59TH ELECTRONIC COMPONENTS AND TECHNOLOGY CONFERENCE, VOLS 1-4
Place of PublicationNEW YORK
PublisherIEEE
Pages1970-1976
Number of pages7
ISBN (Print)978-1-4244-4475-5
DOIs
Publication statusPublished - 2009
Event2009 59th Electronic Components and Technology Conference - San Diego, CA, United States
Duration: 26 May 200929 May 2009

Conference

Conference2009 59th Electronic Components and Technology Conference
Abbreviated titleECTC 2009
CountryUnited States
CitySan Diego, CA
Period26/05/0929/05/09

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