Palladium-catalyzed direct C-H functionalization of benzoquinone

Sarah E. Walker, James A. Jordan-Hore, David G. Johnson, Stuart A. MacGregor*, Ai Lan Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)
144 Downloads (Pure)


A direct Pd-catalyzed C-H functionalization of benzoquinone (BQ) can be controlled to give either mono- or disubstituted BQ, including the installation of two different groups in a one-pot procedure. BQ can now be directly functionalized with aryl, heteroaryl, cycloalkyl, and cyclo-alkene groups and, moreover, the reaction is conducted in environmentally benign water or acetone as solvents.

Original languageEnglish
Pages (from-to)13876-13879
Number of pages4
JournalAngewandte Chemie International Edition
Issue number50
Publication statusPublished - 10 Oct 2014


  • Benzoquinone
  • C-H functionalization
  • Palladium
  • Synthetic methods
  • Water


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