Oxidative stress responses of the yeast Saccharomyces cerevisiae

    Research output: Contribution to journalLiterature review

    563 Citations (Scopus)

    Abstract

    All aerobically growing organisms suffer exposure to oxidative stress, caused by partially reduced forms of molecular oxygen, known as reactive oxygen species (ROS). These are highly reactive and capable of damaging cellular constituents such as DNA, lipids and proteins. Consequently, cells from many different organisms have evolved mechanisms to protect their components against ROS. This review concentrates on the oxidant defence systems of the budding yeast Saccharomyces cerevisiae, which appears to have a number of inducible adaptive stress responses to oxidants, such as H2O2, superoxide anion and lipid peroxidation products. The oxidative stress responses appear to be regulated, at least in part, at the level of transcription and there is considerable overlap between them and many diverse stress responses, allowing the yeast cell to integrate its response towards environmental stress.

    Original languageEnglish
    Pages (from-to)1511-1527
    Number of pages17
    JournalYeast
    Volume14
    Issue number16
    DOIs
    Publication statusPublished - Dec 1998

    Keywords

    • Oxidative stress
    • Saccharomyces cerevisiae
    • Signal transduction
    • Stress response

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