Oxidative stress based-biomarkers in oral carcinogenesis: how far have we gone?

Rania Hanafi, Ioannis Anestopoulos, Georgia-Persephoni Voulgaridou, Rodrigo Franco, Alexandros G Georgakilas, Dominique Ziech, Vasiliki Malamou-Mitsi, Aglaia Pappa, Mihalis I Panayiotidis

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)


    Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
    Original languageEnglish
    Pages (from-to)698-703
    Number of pages6
    JournalCurrent Molecular Medicine
    Issue number6
    Publication statusPublished - Jul 2012


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