Oral cancer accounts for 2-3% of all malignancies and according to the World Health Organization (WHO) is the fifth most common cancer worldwide. On the other hand, "oxidative stress" implies a cellular state whereby reactive oxygen species (ROS) production exceeds its metabolism resulting in excessive ROS accumulation and overwhelmed cellular defenses. Such a state has been shown to be involved in the multistage process of human carcinogenesis (including oral cancer) via many different mechanisms. Amongst them are ROS-induced oxidative modifications on major cellular macromolecules like DNA, proteins and lipids with the resulting byproducts being involved in the pathophysiology of human oral malignant and pre-malignant lesions. Throughout this manuscript, we review the current state of knowledge on the role of these oxidative-modified cellular byproducts in serving as reliable biomarkers for oral cancer detection, prognosis and diagnosis.
Hanafi, R., Anestopoulos, I., Voulgaridou, G-P., Franco, R., Georgakilas, A. G., Ziech, D., Malamou-Mitsi, V., Pappa, A., & Panayiotidis, M. I. (2012). Oxidative stress based-biomarkers in oral carcinogenesis: how far have we gone? Current Molecular Medicine, 12(6), 698-703. https://doi.org/10.2174/156652412800792598