Optical observations of microbubble oscillation in small tubes

David Thomas, Vassilis Sboros, Marcia Emmer, Hendrik J. Vos, Nico de jong

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)


In diagnostic medicine, microbubbles are used as contrast agents to image blood flow. However, the effect of microvessels surrounding the oscillating microbubbles (MBs) is under investigated. Here, oscillations of Definity (Lantheus Imaging) microbubbles in tubes with inner diameter of 25 ¿m and 200 ¿m are compared in response to low acoustic driving pressure, using the ultrahigh speed Brandaris 128 camera, at frame rates of ~12 million frames per second. A significant reduction in oscillation was observed for MBs in the smaller 25 ¿m tube, when compared to those in a 200 ¿m tube. In the 25 ¿m tube, at 50 kPa an increased incidence of MBs which did not oscillate above the noise level of the system was observed (56% of MBs compared to 8% in the 200 ¿m tube), indicating an increased oscillation damping. Unlike theoretical predictions no significant difference was observed between the resonance frequency curves calculated for MBs in 25 ¿m and 200 ¿m tubes. While previous investigators have shown the effect of microvessels on MB oscillation at high ultrasound pressures, the present study provides the first optical images of low amplitude microbubble oscillations in small tubes.
Original languageEnglish
Title of host publication2009 IEEE International Ultrasonics Symposium
Number of pages3
ISBN (Print)9781424443895
Publication statusPublished - 1 Apr 2010
Event2009 IEEE International Ultrasonics Symposium - Rome, Italy
Duration: 20 Sept 200923 Sept 2009


Conference2009 IEEE International Ultrasonics Symposium


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