On-line monitoring of a crystallization process

Patricia Mougin, Alistair Thomas, Derek Wilkinson, Graeme White, Kevin J. Roberts, Norbert Herrmann, Robert Jack, Richard Tweedie

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

The application of ultrasonic spectroscopy for particle-size measurements was investigated during the batch crystallization of (L)-glutamic acid a-polymorph from an aqueous solution. The technique, based on measurements of the attenuation of ultrasonic waves through the suspension, was applied using a prototype ultrasonic spectrometer with a flow-through cell. High-precision measurements of ultrasonic attenuation in the frequency range 7-110 MHz were performed, the deconvolution of which enabled in-process measurement of crystal size distribution and solid concentration throughout the crystallization process. In addition to evincing secondary nucleation, growth and crystal breakage on-line in real time, the experimental results were used to obtain kinetic parameters essential for process design, including secondary nucleation rate and growth rate.

Original languageEnglish
Pages (from-to)373-378
Number of pages6
JournalAIChE Journal
Volume49
Issue number2
DOIs
Publication statusPublished - 1 Feb 2003

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