Abstract
In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: reactant supersaturation via ATR-FFIR spectroscopy; crystal size via acoustic attenuation spectroscopy; particle perfection and polymorphic form via X-ray diffraction; crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements. These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented.
Original language | English |
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Pages (from-to) | 273-287 |
Number of pages | 15 |
Journal | Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals |
Volume | 356 |
Publication status | Published - 2001 |
Event | 14th International Conference on the Chemistry of the Organic Solid State - Cambridge, United Kingdom Duration: 25 Jul 1999 → 30 Jul 1999 |
Keywords
- Batch processing
- Crystallisation
- On-line analytical techniques
- Process mixing scale up