On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals

M. Baker; Zhiyi Cao; D. Dale; P. Erk; L. Ford; H. Groen; D. Latham; R. B. Hammond; X. Lai; K. Liang; D. Merrifield; P. Mougin; R. Oliver; D. Roberts; K. J. Roberts; N. Savelli; A. Thomas; G. White; D. Wilkinson; W. Wood

On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals

M. Baker, Zhiyi Cao, D. Dale, P. Erk, L. Ford, H. Groen, D. Latham, R. B. Hammond, X. Lai, K. Liang, D. Merrifield, P. Mougin, R. Oliver, D. Roberts, K. J. Roberts, N. Savelli, A. Thomas, G. White, D. Wilkinson, W. Wood

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: reactant supersaturation via ATR-FFIR spectroscopy; crystal size via acoustic attenuation spectroscopy; particle perfection and polymorphic form via X-ray diffraction; crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements. These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented.

Original language	English
Pages (from-to)	273-287
Number of pages	15
Journal	Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals
Volume	356
Publication status	Published - 2001
Event	14th International Conference on the Chemistry of the Organic Solid State - Cambridge, United Kingdom Duration: 25 Jul 1999 → 30 Jul 1999

Keywords

Batch processing
Crystallisation
On-line analytical techniques
Process mixing scale up

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Baker, M., Cao, Z., Dale, D., Erk, P., Ford, L., Groen, H., Latham, D., Hammond, R. B., Lai, X., Liang, K., Merrifield, D., Mougin, P., Oliver, R., Roberts, D., Roberts, K. J., Savelli, N., Thomas, A., White, G., Wilkinson, D., & Wood, W. (2001). On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals. Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, 356, 273-287.

Baker, M. ; Cao, Zhiyi ; Dale, D. ; Erk, P. ; Ford, L. ; Groen, H. ; Latham, D. ; Hammond, R. B. ; Lai, X. ; Liang, K. ; Merrifield, D. ; Mougin, P. ; Oliver, R. ; Roberts, D. ; Roberts, K. J. ; Savelli, N. ; Thomas, A. ; White, G. ; Wilkinson, D. ; Wood, W. / On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals. In: Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals. 2001 ; Vol. 356. pp. 273-287.

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title = "On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals",

abstract = "In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: reactant supersaturation via ATR-FFIR spectroscopy; crystal size via acoustic attenuation spectroscopy; particle perfection and polymorphic form via X-ray diffraction; crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements. These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented.",

keywords = "Batch processing, Crystallisation, On-line analytical techniques, Process mixing scale up",

author = "M. Baker and Zhiyi Cao and D. Dale and P. Erk and L. Ford and H. Groen and D. Latham and Hammond, {R. B.} and X. Lai and K. Liang and D. Merrifield and P. Mougin and R. Oliver and D. Roberts and Roberts, {K. J.} and N. Savelli and A. Thomas and G. White and D. Wilkinson and W. Wood",

year = "2001",

language = "English",

volume = "356",

pages = "273--287",

journal = "Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals",

issn = "1058-725X",

publisher = "Taylor & Francis",

note = "14th International Conference on the Chemistry of the Organic Solid State, ICOSS XIV ; Conference date: 25-07-1999 Through 30-07-1999",

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Baker, M, Cao, Z, Dale, D, Erk, P, Ford, L, Groen, H, Latham, D, Hammond, RB, Lai, X, Liang, K, Merrifield, D, Mougin, P, Oliver, R, Roberts, D, Roberts, KJ, Savelli, N, Thomas, A, White, G, Wilkinson, D & Wood, W 2001, 'On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals', Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, vol. 356, pp. 273-287.

On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals. / Baker, M.; Cao, Zhiyi; Dale, D.; Erk, P.; Ford, L.; Groen, H.; Latham, D.; Hammond, R. B.; Lai, X.; Liang, K.; Merrifield, D.; Mougin, P.; Oliver, R.; Roberts, D.; Roberts, K. J.; Savelli, N.; Thomas, A.; White, G.; Wilkinson, D.; Wood, W.

In: Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals, Vol. 356, 2001, p. 273-287.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals

AU - Baker, M.

AU - Cao, Zhiyi

AU - Dale, D.

AU - Erk, P.

AU - Ford, L.

AU - Groen, H.

AU - Latham, D.

AU - Hammond, R. B.

AU - Lai, X.

AU - Liang, K.

AU - Merrifield, D.

AU - Mougin, P.

AU - Oliver, R.

AU - Roberts, D.

AU - Roberts, K. J.

AU - Savelli, N.

AU - Thomas, A.

AU - White, G.

AU - Wilkinson, D.

AU - Wood, W.

PY - 2001

Y1 - 2001

N2 - In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: reactant supersaturation via ATR-FFIR spectroscopy; crystal size via acoustic attenuation spectroscopy; particle perfection and polymorphic form via X-ray diffraction; crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements. These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented.

AB - In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: reactant supersaturation via ATR-FFIR spectroscopy; crystal size via acoustic attenuation spectroscopy; particle perfection and polymorphic form via X-ray diffraction; crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements. These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented.

KW - Batch processing

KW - Crystallisation

KW - On-line analytical techniques

KW - Process mixing scale up

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M3 - Article

VL - 356

SP - 273

EP - 287

JO - Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals

JF - Molecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals

SN - 1058-725X

T2 - 14th International Conference on the Chemistry of the Organic Solid State

Y2 - 25 July 1999 through 30 July 1999

ER -