On-line analytical techniques for monitoring crystallisation processes of organic speciality chemicals

M. Baker, Zhiyi Cao, D. Dale, P. Erk, L. Ford, H. Groen, D. Latham, R. B. Hammond, X. Lai, K. Liang, D. Merrifield, P. Mougin, R. Oliver, D. Roberts, K. J. Roberts, N. Savelli, A. Thomas, G. White, D. Wilkinson, W. Wood

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

In order to examine on-line batch crystallisation processes a new integrated batch process engineering laboratory has been established providing facilities for the on-line measurement and control of: reactant supersaturation via ATR-FFIR spectroscopy; crystal size via acoustic attenuation spectroscopy; particle perfection and polymorphic form via X-ray diffraction; crystallisation on-set and meta-stable zone width via UV vis spectroscopic turbidometric measurements. These facilities are complemented via assessment of reactant mixing as measured via laser doppler anemometry and simulated using multi-phase computational fluid dynamics. An overview of the planned research programme and material systems to be examined are presented.

Original languageEnglish
Pages (from-to)273-287
Number of pages15
JournalMolecular Crystals and Liquid Crystals Science and Technology. Section A. Molecular Crystals and Liquid Crystals
Volume356
Publication statusPublished - 2001
Event14th International Conference on the Chemistry of the Organic Solid State - Cambridge, United Kingdom
Duration: 25 Jul 199930 Jul 1999

Keywords

  • Batch processing
  • Crystallisation
  • On-line analytical techniques
  • Process mixing scale up

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