On-chip modelling of the biophysics of pancreatic ductal adenocarcinoma for assessment with new therapeutics

Delanyo Kpeglo, Margaret Knowles, Malcolm Haddrick, Stephen D. Evans, Sally A. Peyman*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper presents a microfluidic device for the culturing of a pancreatic ductal adenocarcinoma (PDAC) model, towards mimicking the biophysics of PDAC as observed in vivo. As a solid tumour, the biophysical rigidity of PDAC's microenvironment hampers the uptake of therapeutic agents, and understanding the biophysical nature of PDAC is key to effective therapeutic strategies.
Original languageEnglish
Title of host publication24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020
PublisherChemical and Biological Microsystems Society
Pages945-946
Number of pages2
ISBN (Electronic)9781733419017
Publication statusPublished - 2020
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2020
Abbreviated titleMicroTAS 2020
CityVirtual, Online
Period4/10/209/10/20

Keywords

  • Pancreatic Ductal Adenocarcinoma
  • Tumour Tissue Mechanics

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Bioengineering
  • General Chemistry
  • Control and Systems Engineering

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