Off-Chip-Controlled Droplet-on-Demand Method for Precise Sample Handling

Medina Hamidović, Uli Marta, Helen Bridle, Damir Hamidović, Gerold Fink, Robert Wille, Andreas Springer, Werner Haselmayr*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)
53 Downloads (Pure)


We present a simple, stable, and highly reproducible off-chip-controlled method for generating droplets-on-demand. To induce the droplet generation, externally pre-programmed positive pressure pulses are applied to the dispersed phase input while the continuous phase channel remains at constant input pressure. By controlling solely one fluid phase, the method allows for connecting multiple independent dispersed-phase channels to a single continuous channel. Experimental results show that the method allows for a droplet generation frequency of 33 Hz and a high reproducibility of droplets with standard deviations less than 5% of the mean value. Moreover, utilization of the off-chip-controlled method results in the simplicity in chip design and allows rapid (∼5 min) and cost-efficient (0.5 USD) prototyping of the device.

Original languageEnglish
Pages (from-to)9684-9689
Number of pages6
JournalACS Omega
Issue number17
Early online date23 Apr 2020
Publication statusPublished - 5 May 2020

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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