Abstract
Several spiro 2-pyrrolidin-5-ones were obtained by a two-step procedure from N-substituted succinimides, involving spiro cyclisation of N-acyliminium ion intermediates in refluxing trifluoroacetic acid; in all cases cyclisation utilised a tethered aromatic p-nucleophile, and ring-closure followed 5- or 6-exo-trig pathways.
| Original language | English |
|---|---|
| Pages (from-to) | 7115-7118 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 35 |
| Issue number | 38 |
| DOIs | |
| Publication status | Published - 1994 |
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Novel spiro cyclisations of N-acyliminium ions involving an aromatic π-nucleophile. / Bailey, Patrick D.; Morgan, Keith M.; Smith, David I.; Vernon, John M.
In: Tetrahedron Letters, Vol. 35, No. 38, 1994, p. 7115-7118.Research output: Contribution to journal › Article
TY - JOUR
T1 - Novel spiro cyclisations of N-acyliminium ions involving an aromatic π-nucleophile
AU - Bailey, Patrick D.
AU - Morgan, Keith M.
AU - Smith, David I.
AU - Vernon, John M.
PY - 1994
Y1 - 1994
N2 - Several spiro 2-pyrrolidin-5-ones were obtained by a two-step procedure from N-substituted succinimides, involving spiro cyclisation of N-acyliminium ion intermediates in refluxing trifluoroacetic acid; in all cases cyclisation utilised a tethered aromatic p-nucleophile, and ring-closure followed 5- or 6-exo-trig pathways.
AB - Several spiro 2-pyrrolidin-5-ones were obtained by a two-step procedure from N-substituted succinimides, involving spiro cyclisation of N-acyliminium ion intermediates in refluxing trifluoroacetic acid; in all cases cyclisation utilised a tethered aromatic p-nucleophile, and ring-closure followed 5- or 6-exo-trig pathways.
UR - http://www.scopus.com/inward/record.url?scp=0027940177&partnerID=8YFLogxK
U2 - 10.1016/0040-4039(94)88240-1
DO - 10.1016/0040-4039(94)88240-1
M3 - Article
VL - 35
SP - 7115
EP - 7118
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 38
ER -