Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation

Muhammad Mujahid, Natasha Trendafilova, Agnieszka Foltyn Arfa-Kia, Georgina Rosair, Kevin Kavanagh, Michael Devereux, Maureen Walsh, Siobhán McClean, Bernadette S. Creaven, Ivelina Georgieva

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Abstract

Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts have been prepared and characterised by microanalytical data and spectroscopic techniques (IR, 1H, 13C NMR, UV–Vis). The crystal structure of one Ag(I) complex was determined by X-ray diffraction analysis. The experimental spectroscopic data have been interpreted on the basis of molecular structure modeling and subsequent spectra simulation with density functional theory method. The binding modes of the coumarins and phenanthroline ligands (monodentate, bidentate, bridging) to Ag(I) have been theoretically modelled and discussed as to the most probable ligand binding in the series of complexes studied. The antimicrobial and antifungal activities have been determined and the complexes were found to have mostly moderate antibacterial activity but some of the phenanthroline adducts were found to have antifungal activity against the clinically important fungus C. albicans, comparable to that of the commercial agents, Amphotericin B and Ketoconazole. Preliminary investigations into the possible mechanism of action of the silver complexes indicated that they did not interact with DNA via nuclease activity or intercalation but the ability to act as a superoxide dismutase mimetic may be related to their antimicrobial activity.
Original languageEnglish
Pages (from-to)53-67
Number of pages15
JournalJournal of Inorganic Biochemistry
Volume163
Early online date16 Jul 2016
DOIs
Publication statusPublished - Oct 2016

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    Mujahid, M., Trendafilova, N., Arfa-Kia, A. F., Rosair, G., Kavanagh, K., Devereux, M., Walsh, M., McClean, S., Creaven, B. S., & Georgieva, I. (2016). Novel silver(I) complexes of coumarin oxyacetate ligands and their phenanthroline adducts: Biological activity, structural and spectroscopic characterisation. Journal of Inorganic Biochemistry, 163, 53-67. https://doi.org/10.1016/j.jinorgbio.2016.07.010