Novel Coronavirus: Current Understanding of Clinical Features, Diagnosis, Pathogenesis, and Treatment Options

Mohammad Ridwane Mungroo, Naveed Ahmed Khan*, Ruqaiyyah Siddiqui

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Since December 2019, coronavirus disease 2019 (COVID-19) caused by severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in devastating consequencesworldwide and infected more than 350,000 individuals and killed more than 16,000 people.SARS-CoV-2 is the seventh member of the coronavirus family to affect humans. Symptoms ofCOVID-19 include fever (88%), cough (68%), vomiting (5%) and diarrhoea (3.7%), and transmissionof SARS-CoV-2 is thought to occur from human to human via respiratory secretions released by theinfected individuals when coughing and sneezing. COVID-19 can be detected through computedtomography scans and confirmed through molecular diagnostics tools such as polymerase chainreaction. Currently, there are no effective treatments against SARS-CoV-2, hence antiviral drugshave been used to reduce the development of respiratory complications by reducing viral load.The purpose of this review is to provide a comprehensive update on the pathogenesis, clinical aspects,diagnosis, challenges and treatment of SARS-CoV-2 infections.
Original languageEnglish
Article number297
JournalPathogens
Volume9
Issue number4
DOIs
Publication statusPublished - 17 Apr 2020

Keywords

  • coronavirus
  • COVID-19
  • SARS-CoV-2
  • 2019-nCoV
  • treatment
  • diagnosis
  • transmission

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