Novel brominated metabolites from Bryozoa: a functional analysis

Arina L. Maltseva, Olga N. Kotenko, Vladimir A. Kutyumov, Darya A. Matvienko, Alexey L. Shavarda, Michael Kenneth Winson, Andrew N. Ostrovsky

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Marine invertebrates are a promising source of novel natural products with biological activities. The phylum Bryozoa is relatively under-investigated in this context, although a number of compounds with medical potential has been discovered in recent years. Here, we report on the novel group of brominated metabolites from the bryozoan Terminoflustra membranaceatruncata, including analysis of biological activities of the tribrominated terminoflustrindole A (Cm-1) and the structures of the related dibrominated variants terminoflustrindoles B and C. Terminoflustrindole A was previously shown to have fungicidal properties. Although they vary by just one bromine group in each case from terminoflustrindole A, in this study, we report that terminoflustrindoles B and C exhibit no antimicrobial activity in the same assays. In addition to displaying antifungal activity, Terminoflustrindole A was also found to exhibit potent cytotoxic activity when tested against tumour cell lines. The gradient distribution of this compound within the bryozoan colony was demonstrated using LC-MS-analysis.

Original languageEnglish
Pages (from-to)1840-1848
Number of pages9
JournalNatural Product Research
Volume31
Issue number16
Early online date29 Nov 2016
DOIs
Publication statusPublished - 18 Aug 2017

Keywords

  • Alkaloid
  • antitumour activity
  • fungicidal activity
  • metabolites
  • natural products
  • terminoflustrindole

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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