Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology

Vasiliki I. Hatzi; Danae A. Laskaratou; Ifigeneia V. Mavragani; Zacharenia Nikitaki; Anastasios Mangelis; Mihalis I. Panayiotidis; Gabriel E. Pantelias; Georgia I. Terzoudi; Alexandros G. Georgakilas

doi:10.1016/j.canlet.2013.11.018

Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology

Vasiliki I. Hatzi
, Danae A. Laskaratou
, Ifigeneia V. Mavragani
, Zacharenia Nikitaki
, Anastasios Mangelis
, Mihalis I. Panayiotidis
, Gabriel E. Pantelias
, Georgia I. Terzoudi
, Alexandros G. Georgakilas^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.

Original language	English
Pages (from-to)	34-42
Number of pages	9
Journal	Cancer Letters
Volume	356
Issue number	1
DOIs	https://doi.org/10.1016/j.canlet.2013.11.018
Publication status	Published - Jan 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Bystander effects
Carcinogenesis
In vivo
Ionizing radiation
Non-targeted effects
Radiobiology

ASJC Scopus subject areas

Cancer Research
Oncology

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10.1016/j.canlet.2013.11.018

Cite this

@article{18f68de661ff4178951589c4a6c0c607,

title = "Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology",

abstract = "Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.",

keywords = "Bystander effects, Carcinogenesis, In vivo, Ionizing radiation, Non-targeted effects, Radiobiology",

author = "Hatzi, \{Vasiliki I.\} and Laskaratou, \{Danae A.\} and Mavragani, \{Ifigeneia V.\} and Zacharenia Nikitaki and Anastasios Mangelis and Panayiotidis, \{Mihalis I.\} and Pantelias, \{Gabriel E.\} and Terzoudi, \{Georgia I.\} and Georgakilas, \{Alexandros G.\}",

year = "2015",

month = jan,

doi = "10.1016/j.canlet.2013.11.018",

language = "English",

volume = "356",

pages = "34--42",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Non-targeted radiation effects in vivo

T2 - A critical glance of the future in radiobiology

AU - Hatzi, Vasiliki I.

AU - Laskaratou, Danae A.

AU - Mavragani, Ifigeneia V.

AU - Nikitaki, Zacharenia

AU - Mangelis, Anastasios

AU - Panayiotidis, Mihalis I.

AU - Pantelias, Gabriel E.

AU - Terzoudi, Georgia I.

AU - Georgakilas, Alexandros G.

PY - 2015/1

Y1 - 2015/1

N2 - Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.

AB - Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.

KW - Bystander effects

KW - Carcinogenesis

KW - In vivo

KW - Ionizing radiation

KW - Non-targeted effects

KW - Radiobiology

U2 - 10.1016/j.canlet.2013.11.018

DO - 10.1016/j.canlet.2013.11.018

M3 - Article

AN - SCOPUS:84912535002

SN - 0304-3835

VL - 356

SP - 34

EP - 42

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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