Non-targeted radiation effects in vivo: A critical glance of the future in radiobiology

Vasiliki I. Hatzi, Danae A. Laskaratou, Ifigeneia V. Mavragani, Zacharenia Nikitaki, Anastasios Mangelis, Mihalis I. Panayiotidis, Gabriel E. Pantelias, Georgia I. Terzoudi, Alexandros G. Georgakilas*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    50 Citations (Scopus)


    Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.

    Original languageEnglish
    Pages (from-to)34-42
    Number of pages9
    JournalCancer Letters
    Issue number1
    Publication statusPublished - Jan 2015


    • Bystander effects
    • Carcinogenesis
    • In vivo
    • Ionizing radiation
    • Non-targeted effects
    • Radiobiology

    ASJC Scopus subject areas

    • Cancer Research
    • Oncology


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