TY - JOUR
T1 - Non-targeted radiation effects in vivo
T2 - A critical glance of the future in radiobiology
AU - Hatzi, Vasiliki I.
AU - Laskaratou, Danae A.
AU - Mavragani, Ifigeneia V.
AU - Nikitaki, Zacharenia
AU - Mangelis, Anastasios
AU - Panayiotidis, Mihalis I.
AU - Pantelias, Gabriel E.
AU - Terzoudi, Georgia I.
AU - Georgakilas, Alexandros G.
PY - 2015/1
Y1 - 2015/1
N2 - Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.
AB - Radiation-induced bystander effects (RIBE), demonstrate the induction of biological non-targeted effects in cells which have not directly hit by radiation or by free radicals produced by ionization events. Although RIBE have been demonstrated using a variety of biological endpoints the mechanism(s) of this phenomenon still remain unclear. The controversial results of the in vitro RIBE and the evidence of non-targeted effects in various in vivo systems are discussed. The experimental evidence on RIBE, indicate that a more analytical and mechanistic in depth approach is needed to secure an answer to one of the most intriguing questions in radiobiology.
KW - Bystander effects
KW - Carcinogenesis
KW - In vivo
KW - Ionizing radiation
KW - Non-targeted effects
KW - Radiobiology
U2 - 10.1016/j.canlet.2013.11.018
DO - 10.1016/j.canlet.2013.11.018
M3 - Article
AN - SCOPUS:84912535002
SN - 0304-3835
VL - 356
SP - 34
EP - 42
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
