Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

Maïwenn Kersaudy-Kerhoas; Antonio Liga; Appan Roychoudhury; Marilena Stamouli; Rhiannon Grant; Damaso Sanchez Carrera; Holger Schulze; Witold Szymon Mielczarek; Wilna Oosthuyzen; Juan F. Quintana; Paul Dickinson; Amy H. Buck; Nicholas R. Leslie; Jurgen Haas; Till T. Bachmann; James W. Dear

Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

Maïwenn Kersaudy-Kerhoas^*
, Antonio Liga
, Appan Roychoudhury
, Marilena Stamouli
, Rhiannon Grant
, Damaso Sanchez Carrera
, Holger Schulze
, Witold Szymon Mielczarek
, Wilna Oosthuyzen
, Juan F. Quintana
, Paul Dickinson
, Amy H. Buck
, Nicholas R. Leslie
, Jurgen Haas
, Till T. Bachmann
, James W. Dear

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

Original language	English
Title of host publication	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	564-565
Number of pages	2
ISBN (Electronic)	9781733419048
Publication status	Published - 23 Oct 2022
Event	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022 - Hybrid, Hangzhou, China Duration: 23 Oct 2022 → 27 Oct 2022 https://microtasconferences.org/microtas2022/

Conference

Conference	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022
Abbreviated title	MicroTAS 2022
Country/Territory	China
City	Hybrid, Hangzhou
Period	23/10/22 → 27/10/22
Internet address	https://microtasconferences.org/microtas2022/

Keywords

Blood
Drug-Induced Liver Injury
MicroRNA
miR-122

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering
General Chemistry
Control and Systems Engineering

Access to Document

https://www.research.ed.ac.uk/en/publications/near-patient-extraction-and-detection-of-mir-122-microrna-biomark

Cite this

Kersaudy-Kerhoas, M., Liga, A., Roychoudhury, A., Stamouli, M., Grant, R., Carrera, D. S., Schulze, H., Mielczarek, W. S., Oosthuyzen, W., Quintana, J. F., Dickinson, P., Buck, A. H., Leslie, N. R., Haas, J., Bachmann, T. T., & Dear, J. W. (2022). Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 564-565). Chemical and Biological Microsystems Society. https://www.research.ed.ac.uk/en/publications/near-patient-extraction-and-detection-of-mir-122-microrna-biomark

@inproceedings{7afb7e1b2d4d4142a8fdaac75f3be026,

title = "Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics",

abstract = "Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.",

keywords = "Blood, Drug-Induced Liver Injury, MicroRNA, miR-122",

author = "Ma{\"i}wenn Kersaudy-Kerhoas and Antonio Liga and Appan Roychoudhury and Marilena Stamouli and Rhiannon Grant and Carrera, \{Damaso Sanchez\} and Holger Schulze and Mielczarek, \{Witold Szymon\} and Wilna Oosthuyzen and Quintana, \{Juan F.\} and Paul Dickinson and Buck, \{Amy H.\} and Leslie, \{Nicholas R.\} and Jurgen Haas and Bachmann, \{Till T.\} and Dear, \{James W.\}",

note = "Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",

year = "2022",

month = oct,

day = "23",

language = "English",

pages = "564--565",

booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

url = "https://microtasconferences.org/microtas2022/",

}

Kersaudy-Kerhoas, M, Liga, A, Roychoudhury, A, Stamouli, M, Grant, R, Carrera, DS, Schulze, H, Mielczarek, WS, Oosthuyzen, W, Quintana, JF, Dickinson, P, Buck, AH, Leslie, NR, Haas, J, Bachmann, TT & Dear, JW 2022, Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 564-565, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022, Hybrid, Hangzhou, China, 23/10/22. <https://www.research.ed.ac.uk/en/publications/near-patient-extraction-and-detection-of-mir-122-microrna-biomark>

Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics. / Kersaudy-Kerhoas, Maïwenn; Liga, Antonio; Roychoudhury, Appan et al.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. p. 564-565.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

AU - Kersaudy-Kerhoas, Maïwenn

AU - Liga, Antonio

AU - Roychoudhury, Appan

AU - Stamouli, Marilena

AU - Grant, Rhiannon

AU - Carrera, Damaso Sanchez

AU - Schulze, Holger

AU - Mielczarek, Witold Szymon

AU - Oosthuyzen, Wilna

AU - Quintana, Juan F.

AU - Dickinson, Paul

AU - Buck, Amy H.

AU - Leslie, Nicholas R.

AU - Haas, Jurgen

AU - Bachmann, Till T.

AU - Dear, James W.

PY - 2022/10/23

Y1 - 2022/10/23

N2 - Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

AB - Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

KW - Blood

KW - Drug-Induced Liver Injury

KW - MicroRNA

KW - miR-122

UR - https://www.scopus.com/pages/publications/85175696283

M3 - Conference contribution

AN - SCOPUS:85175696283

SP - 564

EP - 565

BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022

Y2 - 23 October 2022 through 27 October 2022

ER -

Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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