Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

Maïwenn Kersaudy-Kerhoas; Antonio Liga; Appan Roychoudhury; Marilena Stamouli; Rhiannon Grant; Damaso Sanchez Carrera; Holger Schulze; Witold Szymon Mielczarek; Wilna Oosthuyzen; Juan F. Quintana; Paul Dickinson; Amy H. Buck; Nicholas R. Leslie; Jurgen Haas; Till T. Bachmann; James W. Dear

Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

Maïwenn Kersaudy-Kerhoas^*, Antonio Liga, Appan Roychoudhury, Marilena Stamouli, Rhiannon Grant, Damaso Sanchez Carrera, Holger Schulze, Witold Szymon Mielczarek, Wilna Oosthuyzen, Juan F. Quintana, Paul Dickinson, Amy H. Buck, Nicholas R. Leslie, Jurgen Haas, Till T. Bachmann, James W. Dear

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

Original language	English
Title of host publication	MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences
Publisher	Chemical and Biological Microsystems Society
Pages	564-565
Number of pages	2
ISBN (Electronic)	9781733419048
Publication status	Published - 23 Oct 2022
Event	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022 - Hybrid, Hangzhou, China Duration: 23 Oct 2022 → 27 Oct 2022 https://microtasconferences.org/microtas2022/

Conference

Conference	26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022
Abbreviated title	MicroTAS 2022
Country/Territory	China
City	Hybrid, Hangzhou
Period	23/10/22 → 27/10/22
Internet address	https://microtasconferences.org/microtas2022/

Keywords

Blood
Drug-Induced Liver Injury
MicroRNA
miR-122

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering
General Chemistry
Control and Systems Engineering

Access to Document

https://www.research.ed.ac.uk/en/publications/near-patient-extraction-and-detection-of-mir-122-microrna-biomark

Cite this

Kersaudy-Kerhoas, M., Liga, A., Roychoudhury, A., Stamouli, M., Grant, R., Carrera, D. S., Schulze, H., Mielczarek, W. S., Oosthuyzen, W., Quintana, J. F., Dickinson, P., Buck, A. H., Leslie, N. R., Haas, J., Bachmann, T. T., & Dear, J. W. (2022). Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics. In MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 564-565). Chemical and Biological Microsystems Society. https://www.research.ed.ac.uk/en/publications/near-patient-extraction-and-detection-of-mir-122-microrna-biomark

@inproceedings{7afb7e1b2d4d4142a8fdaac75f3be026,

title = "Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics",

abstract = "Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.",

keywords = "Blood, Drug-Induced Liver Injury, MicroRNA, miR-122",

author = "Ma{\"i}wenn Kersaudy-Kerhoas and Antonio Liga and Appan Roychoudhury and Marilena Stamouli and Rhiannon Grant and Carrera, {Damaso Sanchez} and Holger Schulze and Mielczarek, {Witold Szymon} and Wilna Oosthuyzen and Quintana, {Juan F.} and Paul Dickinson and Buck, {Amy H.} and Leslie, {Nicholas R.} and Jurgen Haas and Bachmann, {Till T.} and Dear, {James W.}",

note = "Publisher Copyright: {\textcopyright} 2022 MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022, MicroTAS 2022 ; Conference date: 23-10-2022 Through 27-10-2022",

year = "2022",

month = oct,

day = "23",

language = "English",

pages = "564--565",

booktitle = "MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences",

publisher = "Chemical and Biological Microsystems Society",

url = "https://microtasconferences.org/microtas2022/",

}

Kersaudy-Kerhoas, M, Liga, A, Roychoudhury, A, Stamouli, M, Grant, R, Carrera, DS, Schulze, H, Mielczarek, WS, Oosthuyzen, W, Quintana, JF, Dickinson, P, Buck, AH, Leslie, NR, Haas, J, Bachmann, TT & Dear, JW 2022, Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics. in MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, pp. 564-565, 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022, Hybrid, Hangzhou, China, 23/10/22. <https://www.research.ed.ac.uk/en/publications/near-patient-extraction-and-detection-of-mir-122-microrna-biomark>

Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics. / Kersaudy-Kerhoas, Maïwenn; Liga, Antonio; Roychoudhury, Appan et al.
MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, 2022. p. 564-565.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

AU - Kersaudy-Kerhoas, Maïwenn

AU - Liga, Antonio

AU - Roychoudhury, Appan

AU - Stamouli, Marilena

AU - Grant, Rhiannon

AU - Carrera, Damaso Sanchez

AU - Schulze, Holger

AU - Mielczarek, Witold Szymon

AU - Oosthuyzen, Wilna

AU - Quintana, Juan F.

AU - Dickinson, Paul

AU - Buck, Amy H.

AU - Leslie, Nicholas R.

AU - Haas, Jurgen

AU - Bachmann, Till T.

AU - Dear, James W.

PY - 2022/10/23

Y1 - 2022/10/23

N2 - Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

AB - Drug Induced Liver Injury (DILI) has a high incidence rate across the globe, particularly in mainland China where its estimated incidence in the general population can reach over 23 cases per 100,000. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Here we report a novel platform combining a microfluidic cartridge extraction and Electro-Impedance Spectroscopy (EIS), and demonstrate a proof-of-concept point-of-care diagnostic test of DILI on clinical patient samples.

KW - Blood

KW - Drug-Induced Liver Injury

KW - MicroRNA

KW - miR-122

UR - http://www.scopus.com/inward/record.url?scp=85175696283&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85175696283

SP - 564

EP - 565

BT - MicroTAS 2022 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences

PB - Chemical and Biological Microsystems Society

T2 - 26th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2022

Y2 - 23 October 2022 through 27 October 2022

ER -

Near-patient Extraction and Detection of MIR-122 Microrna Biomarker for Drug-induced Liver Injury Diagnostics

Abstract

Conference

Keywords

ASJC Scopus subject areas

Access to Document

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