Natural variation of model mutant phenotypes in Ciona intestinalis

Paolo Sordino; Nikos Andreakis; Euan R Brown; Nicola I Leccia; Paola Squarzoni; Raffaella Tarallo; Christian Alfano; Luigi Caputi; Palmira D'Ambrosio; Paola Daniele; Enrico D'Aniello; Salvatore D'Aniello; Sylvie Maiella; Valentina Miraglia; Monia Teresa Russo; Gerarda Sorrenti; Margherita Branno; Lucio Cariello; Paola Cirino; Annamaria Locascio; Antonietta Spagnuolo; Laura Zanetti; Filomena Ristoratore

doi:10.1371/journal.pone.0002344

Natural variation of model mutant phenotypes in Ciona intestinalis

Paolo Sordino, Nikos Andreakis, Euan R Brown, Nicola I Leccia, Paola Squarzoni, Raffaella Tarallo, Christian Alfano, Luigi Caputi, Palmira D'Ambrosio, Paola Daniele, Enrico D'Aniello, Salvatore D'Aniello, Sylvie Maiella, Valentina Miraglia, Monia Teresa Russo, Gerarda Sorrenti, Margherita Branno, Lucio Cariello, Paola Cirino, Annamaria LocascioAntonietta Spagnuolo, Laura Zanetti, Filomena Ristoratore

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Abstract

The study of ascidians (Chordata, Tunicata) has made a considerable contribution to our understanding of the origin and evolution of basal chordates. To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the systematic identification of new mutations. In addition to the significance of developmental variation for phenotype-driven studies, this approach can encompass important implications in evolutionary and population biology.

Original language	English
Article number	e2344
Journal	PLoS ONE
Volume	3
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0002344
Publication status	Published - 2008

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Sordino, P., Andreakis, N., Brown, E. R., Leccia, N. I., Squarzoni, P., Tarallo, R., Alfano, C., Caputi, L., D'Ambrosio, P., Daniele, P., D'Aniello, E., D'Aniello, S., Maiella, S., Miraglia, V., Russo, M. T., Sorrenti, G., Branno, M., Cariello, L., Cirino, P., ... Ristoratore, F. (2008). Natural variation of model mutant phenotypes in Ciona intestinalis. PLoS ONE, 3(6), [e2344]. https://doi.org/10.1371/journal.pone.0002344

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abstract = "The study of ascidians (Chordata, Tunicata) has made a considerable contribution to our understanding of the origin and evolution of basal chordates. To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the systematic identification of new mutations. In addition to the significance of developmental variation for phenotype-driven studies, this approach can encompass important implications in evolutionary and population biology.",

author = "Paolo Sordino and Nikos Andreakis and Brown, {Euan R} and Leccia, {Nicola I} and Paola Squarzoni and Raffaella Tarallo and Christian Alfano and Luigi Caputi and Palmira D'Ambrosio and Paola Daniele and Enrico D'Aniello and Salvatore D'Aniello and Sylvie Maiella and Valentina Miraglia and Russo, {Monia Teresa} and Gerarda Sorrenti and Margherita Branno and Lucio Cariello and Paola Cirino and Annamaria Locascio and Antonietta Spagnuolo and Laura Zanetti and Filomena Ristoratore",

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Sordino, P, Andreakis, N, Brown, ER, Leccia, NI, Squarzoni, P, Tarallo, R, Alfano, C, Caputi, L, D'Ambrosio, P, Daniele, P, D'Aniello, E, D'Aniello, S, Maiella, S, Miraglia, V, Russo, MT, Sorrenti, G, Branno, M, Cariello, L, Cirino, P, Locascio, A, Spagnuolo, A, Zanetti, L & Ristoratore, F 2008, 'Natural variation of model mutant phenotypes in Ciona intestinalis', PLoS ONE, vol. 3, no. 6, e2344. https://doi.org/10.1371/journal.pone.0002344

TY - JOUR

T1 - Natural variation of model mutant phenotypes in Ciona intestinalis

AU - Sordino, Paolo

AU - Andreakis, Nikos

AU - Brown, Euan R

AU - Leccia, Nicola I

AU - Squarzoni, Paola

AU - Tarallo, Raffaella

AU - Alfano, Christian

AU - Caputi, Luigi

AU - D'Ambrosio, Palmira

AU - Daniele, Paola

AU - D'Aniello, Enrico

AU - D'Aniello, Salvatore

AU - Maiella, Sylvie

AU - Miraglia, Valentina

AU - Russo, Monia Teresa

AU - Sorrenti, Gerarda

AU - Branno, Margherita

AU - Cariello, Lucio

AU - Cirino, Paola

AU - Locascio, Annamaria

AU - Spagnuolo, Antonietta

AU - Zanetti, Laura

AU - Ristoratore, Filomena

PY - 2008

Y1 - 2008

N2 - The study of ascidians (Chordata, Tunicata) has made a considerable contribution to our understanding of the origin and evolution of basal chordates. To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the systematic identification of new mutations. In addition to the significance of developmental variation for phenotype-driven studies, this approach can encompass important implications in evolutionary and population biology.

AB - The study of ascidians (Chordata, Tunicata) has made a considerable contribution to our understanding of the origin and evolution of basal chordates. To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the systematic identification of new mutations. In addition to the significance of developmental variation for phenotype-driven studies, this approach can encompass important implications in evolutionary and population biology.

U2 - 10.1371/journal.pone.0002344

DO - 10.1371/journal.pone.0002344

M3 - Article

C2 - 18523552

SN - 1932-6203

VL - 3

JO - PLoS ONE

JF - PLoS ONE

IS - 6

M1 - e2344

ER -

Natural variation of model mutant phenotypes in Ciona intestinalis

Abstract

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