Natural variation of model mutant phenotypes in Ciona intestinalis

Paolo Sordino, Nikos Andreakis, Euan R Brown, Nicola I Leccia, Paola Squarzoni, Raffaella Tarallo, Christian Alfano, Luigi Caputi, Palmira D'Ambrosio, Paola Daniele, Enrico D'Aniello, Salvatore D'Aniello, Sylvie Maiella, Valentina Miraglia, Monia Teresa Russo, Gerarda Sorrenti, Margherita Branno, Lucio Cariello, Paola Cirino, Annamaria LocascioAntonietta Spagnuolo, Laura Zanetti, Filomena Ristoratore

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Abstract

The study of ascidians (Chordata, Tunicata) has made a considerable contribution to our understanding of the origin and evolution of basal chordates. To provide further information to support forward genetics in Ciona intestinalis, we used a combination of natural variation and neutral population genetics as an approach for the systematic identification of new mutations. In addition to the significance of developmental variation for phenotype-driven studies, this approach can encompass important implications in evolutionary and population biology.
Original languageEnglish
Article numbere2344
JournalPLoS ONE
Volume3
Issue number6
DOIs
Publication statusPublished - 2008

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    Sordino, P., Andreakis, N., Brown, E. R., Leccia, N. I., Squarzoni, P., Tarallo, R., Alfano, C., Caputi, L., D'Ambrosio, P., Daniele, P., D'Aniello, E., D'Aniello, S., Maiella, S., Miraglia, V., Russo, M. T., Sorrenti, G., Branno, M., Cariello, L., Cirino, P., ... Ristoratore, F. (2008). Natural variation of model mutant phenotypes in Ciona intestinalis. PLoS ONE, 3(6), [e2344]. https://doi.org/10.1371/journal.pone.0002344