Natural Products for Targeting Acanthamoeba spp.

Yassmin Isse Wehelie; Aishath Leesha Nasih; Ayaz Anwar; Ruqaiyyah Siddiqui; Sutherland Kester Maciver; Naveed Ahmed Khan

doi:10.2174/2211352519666211119091316

Natural Products for Targeting Acanthamoeba spp.

Yassmin Isse Wehelie, Aishath Leesha Nasih, Ayaz Anwar^*, Ruqaiyyah Siddiqui, Sutherland Kester Maciver, Naveed Ahmed Khan^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

1 Citation (Scopus)

Abstract

Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

Original language	English
Article number	e191121198116
Journal	Anti-Infective Agents
Volume	20
Issue number	3
Early online date	16 Feb 2022
DOIs	https://doi.org/10.2174/2211352519666211119091316
Publication status	Published - Jun 2022

Keywords

granulomatous amoebic encephalitis
keratitis
Natural products
parasite
protozoa
treatment

ASJC Scopus subject areas

Pharmacology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2174/2211352519666211119091316

Cite this

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title = "Natural Products for Targeting Acanthamoeba spp.",

abstract = "Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.",

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author = "Wehelie, {Yassmin Isse} and Nasih, {Aishath Leesha} and Ayaz Anwar and Ruqaiyyah Siddiqui and Maciver, {Sutherland Kester} and Khan, {Naveed Ahmed}",

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doi = "10.2174/2211352519666211119091316",

language = "English",

volume = "20",

journal = "Anti-Infective Agents",

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T1 - Natural Products for Targeting Acanthamoeba spp.

AU - Wehelie, Yassmin Isse

AU - Nasih, Aishath Leesha

AU - Anwar, Ayaz

AU - Siddiqui, Ruqaiyyah

AU - Maciver, Sutherland Kester

AU - Khan, Naveed Ahmed

PY - 2022/6

Y1 - 2022/6

N2 - Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

AB - Pathogenic Acanthamoeba is responsible for causing serious eye and fatal brain infections. A successful prognosis remains elusive despite advances in chemotherapeutics and supportive care. Natural products of medicinal value remain a promising source for drug development due to their broad-spectrum antimicrobial activities. Herein, we discuss anti-Acanthamoebic properties of natural products originating from plants, marine, and microbial sources that could be exploited as a potential avenue for drug discovery against infections caused by Acanthamoeba.

KW - granulomatous amoebic encephalitis

KW - keratitis

KW - Natural products

KW - parasite

KW - protozoa

KW - treatment

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U2 - 10.2174/2211352519666211119091316

DO - 10.2174/2211352519666211119091316

M3 - Short survey

AN - SCOPUS:85132873726

SN - 2211-3525

VL - 20

JO - Anti-Infective Agents

JF - Anti-Infective Agents

IS - 3

M1 - e191121198116

ER -

Natural Products for Targeting Acanthamoeba spp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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