Nanostructure and pore size control of template-free synthesised mesoporous magnesium carbonate

Ocean Cheung; Peng Zhang; Sara Frykstrand; Haoquan Zheng; Taimin Yang; Marco Sommariva; Xiaodong Zou; Maria Strømme

doi:10.1039/c6ra14171d

Nanostructure and pore size control of template-free synthesised mesoporous magnesium carbonate

Ocean Cheung, Peng Zhang, Sara Frykstrand, Haoquan Zheng, Taimin Yang, Marco Sommariva, Xiaodong Zou, Maria Strømme^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

The structure of mesoporous magnesium carbonate (MMC) first presented in 2013 is investigated using a bottom-up approach. MMC is found to be built from the aggregation of nanoparticles of amorphous MgCO₃ and MgO with a coating of amorphous MgCO₃. The nanoparticles have dimensions of approximately 2-5 nm as observed using transmission electron microscopy and the aggregation of the particles creates the pore structure of MMC. We further show that the average pore diameter of MMC can be controlled by varying the temperature during the powder formation process and demonstrate that altering the pore size opens the possibility to tune the amorphous phase stabilisation properties that MMC exerts on poorly soluble drug compounds. Specifically, we show the loading and release of the antifungal drug itraconazole using MMC as a drug carrier.

Original language	English
Pages (from-to)	74241-74249
Number of pages	9
Journal	RSC Advances
Volume	6
Issue number	78
Early online date	1 Aug 2016
DOIs	https://doi.org/10.1039/c6ra14171d
Publication status	Published - 2016

ASJC Scopus subject areas

Chemical Engineering(all)
Chemistry(all)

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abstract = "The structure of mesoporous magnesium carbonate (MMC) first presented in 2013 is investigated using a bottom-up approach. MMC is found to be built from the aggregation of nanoparticles of amorphous MgCO3 and MgO with a coating of amorphous MgCO3. The nanoparticles have dimensions of approximately 2-5 nm as observed using transmission electron microscopy and the aggregation of the particles creates the pore structure of MMC. We further show that the average pore diameter of MMC can be controlled by varying the temperature during the powder formation process and demonstrate that altering the pore size opens the possibility to tune the amorphous phase stabilisation properties that MMC exerts on poorly soluble drug compounds. Specifically, we show the loading and release of the antifungal drug itraconazole using MMC as a drug carrier.",

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AU - Cheung, Ocean

AU - Zhang, Peng

AU - Frykstrand, Sara

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AU - Yang, Taimin

AU - Sommariva, Marco

AU - Zou, Xiaodong

AU - Strømme, Maria

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AB - The structure of mesoporous magnesium carbonate (MMC) first presented in 2013 is investigated using a bottom-up approach. MMC is found to be built from the aggregation of nanoparticles of amorphous MgCO3 and MgO with a coating of amorphous MgCO3. The nanoparticles have dimensions of approximately 2-5 nm as observed using transmission electron microscopy and the aggregation of the particles creates the pore structure of MMC. We further show that the average pore diameter of MMC can be controlled by varying the temperature during the powder formation process and demonstrate that altering the pore size opens the possibility to tune the amorphous phase stabilisation properties that MMC exerts on poorly soluble drug compounds. Specifically, we show the loading and release of the antifungal drug itraconazole using MMC as a drug carrier.

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Nanostructure and pore size control of template-free synthesised mesoporous magnesium carbonate

Abstract

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