Nanopatches for Vaccine Delivery

M. L. Crichton, Mark A. F. Kendall

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Needle-free vaccine delivery methods have the potential for pain-free, improved immunogenicity vaccination by delivering directly into the skin. Herein we give a brief overview of approaches for this and subsequently provide a detailed description of the Nanopatch approach. This work details the design, hypothesized mode of action, and the immune responses generated from this method. Additionally, the potential for eliminating the cold chain in vaccines is discussed, and the potential long-term implications of these devices. These are explained in the context of the field of microneedles, which have not otherwise been able to achieve the performance of the Nanopatch.

Original languageEnglish
Title of host publicationMicro- and Nanotechnology in Vaccine Development
PublisherElsevier
Pages343-356
Number of pages14
ISBN (Electronic)9780323400299
ISBN (Print)9780323399814
DOIs
Publication statusPublished - 2017

Keywords

  • Dendritic cells
  • Immune response
  • Skin
  • Skin mechanics
  • Vaccination
  • Vaccination device

ASJC Scopus subject areas

  • Medicine(all)

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