Nanobubbles for therapeutic delivery: Production, stability and current prospects

Damien V. B. Batchelor; Fern J. Armistead; Nicola Ingram; Sally A. Peyman; James R. McLaughlan; P. Louise Coletta; Stephen D. Evans

doi:10.1016/j.cocis.2021.101456

Nanobubbles for therapeutic delivery: Production, stability and current prospects

Damien V. B. Batchelor, Fern J. Armistead, Nicola Ingram, Sally A. Peyman, James R. McLaughlan, P. Louise Coletta, Stephen D. Evans^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

38 Citations (Scopus)

Abstract

Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery. In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.

Original language	English
Article number	101456
Journal	Current Opinion in Colloid and Interface Science
Volume	54
Early online date	30 Mar 2021
DOIs	https://doi.org/10.1016/j.cocis.2021.101456
Publication status	Published - Aug 2021

Keywords

Biomedical
Cancer
Chemotherapy
Drug delivery
Nanobubbles
Theranostic
Therapeutic
Triggered release
Ultrafine bubbles
Ultrasound

ASJC Scopus subject areas

Surfaces and Interfaces
Physical and Theoretical Chemistry
Polymers and Plastics
Colloid and Surface Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cocis.2021.101456

Cite this

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title = "Nanobubbles for therapeutic delivery: Production, stability and current prospects",

abstract = "Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery. In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.",

keywords = "Biomedical, Cancer, Chemotherapy, Drug delivery, Nanobubbles, Theranostic, Therapeutic, Triggered release, Ultrafine bubbles, Ultrasound",

author = "Batchelor, {Damien V. B.} and Armistead, {Fern J.} and Nicola Ingram and Peyman, {Sally A.} and McLaughlan, {James R.} and Coletta, {P. Louise} and Evans, {Stephen D.}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = aug,

doi = "10.1016/j.cocis.2021.101456",

language = "English",

volume = "54",

journal = "Current Opinion in Colloid and Interface Science",

issn = "1359-0294",

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TY - JOUR

T1 - Nanobubbles for therapeutic delivery

T2 - Production, stability and current prospects

AU - Batchelor, Damien V. B.

AU - Armistead, Fern J.

AU - Ingram, Nicola

AU - Peyman, Sally A.

AU - McLaughlan, James R.

AU - Coletta, P. Louise

AU - Evans, Stephen D.

PY - 2021/8

Y1 - 2021/8

N2 - Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery. In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.

AB - Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery. In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.

KW - Biomedical

KW - Cancer

KW - Chemotherapy

KW - Drug delivery

KW - Nanobubbles

KW - Theranostic

KW - Therapeutic

KW - Triggered release

KW - Ultrafine bubbles

KW - Ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85105312143&partnerID=8YFLogxK

U2 - 10.1016/j.cocis.2021.101456

DO - 10.1016/j.cocis.2021.101456

M3 - Review article

AN - SCOPUS:85105312143

SN - 1359-0294

VL - 54

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

M1 - 101456

ER -

Nanobubbles for therapeutic delivery: Production, stability and current prospects

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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