Nano-TiO2-feasibility and challenges for human health risk assessment based on open literature

Frans M. Christensen, Helinor J. Johnston, Vicki Stone, Robert J. Aitken, Steve Hankin, Sheona Peters, Karin Aschberger

    Research output: Contribution to journalArticle

    Abstract

    This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-titanium-dioxide (nano-TiO2) based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision-making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also short-term inhalation following spray applications may cause risks. Main future work should focus on generating occupational and consumer inhalation exposure data, as well as toxicity data on absorption following inhalation, repeated dermal contact, and contact with damaged skin. Also relevant seems further information on possible neurotoxicity and genotoxicity/carcinogenicity, as well as establishing a No Observed Adverse Effect Level (NOAEL) for acute inhalation of nano-TiO2.

    Original languageEnglish
    Pages (from-to)110-124
    Number of pages15
    JournalNanotoxicology
    Volume5
    Issue number2
    DOIs
    Publication statusPublished - Jun 2011

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    Inhalation
    Health
    No-Observed-Adverse-Effect Level
    Inhalation Exposure
    Skin
    Workplace
    Decision Making
    titanium dioxide

    Cite this

    Christensen, Frans M. ; Johnston, Helinor J. ; Stone, Vicki ; Aitken, Robert J. ; Hankin, Steve ; Peters, Sheona ; Aschberger, Karin. / Nano-TiO2-feasibility and challenges for human health risk assessment based on open literature. In: Nanotoxicology. 2011 ; Vol. 5, No. 2. pp. 110-124.
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    Nano-TiO2-feasibility and challenges for human health risk assessment based on open literature. / Christensen, Frans M.; Johnston, Helinor J.; Stone, Vicki; Aitken, Robert J.; Hankin, Steve; Peters, Sheona; Aschberger, Karin.

    In: Nanotoxicology, Vol. 5, No. 2, 06.2011, p. 110-124.

    Research output: Contribution to journalArticle

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