TY - JOUR
T1 - Nano-TiO2-feasibility and challenges for human health risk assessment based on open literature
AU - Christensen, Frans M.
AU - Johnston, Helinor J.
AU - Stone, Vicki
AU - Aitken, Robert J.
AU - Hankin, Steve
AU - Peters, Sheona
AU - Aschberger, Karin
PY - 2011/6
Y1 - 2011/6
N2 - This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-titanium-dioxide (nano-TiO2) based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision-making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also short-term inhalation following spray applications may cause risks. Main future work should focus on generating occupational and consumer inhalation exposure data, as well as toxicity data on absorption following inhalation, repeated dermal contact, and contact with damaged skin. Also relevant seems further information on possible neurotoxicity and genotoxicity/carcinogenicity, as well as establishing a No Observed Adverse Effect Level (NOAEL) for acute inhalation of nano-TiO2.
AB - This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-titanium-dioxide (nano-TiO2) based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision-making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also short-term inhalation following spray applications may cause risks. Main future work should focus on generating occupational and consumer inhalation exposure data, as well as toxicity data on absorption following inhalation, repeated dermal contact, and contact with damaged skin. Also relevant seems further information on possible neurotoxicity and genotoxicity/carcinogenicity, as well as establishing a No Observed Adverse Effect Level (NOAEL) for acute inhalation of nano-TiO2.
UR - http://www.scopus.com/inward/record.url?scp=79957828095&partnerID=8YFLogxK
U2 - 10.3109/17435390.2010.504899
DO - 10.3109/17435390.2010.504899
M3 - Article
C2 - 21609135
VL - 5
SP - 110
EP - 124
JO - Nanotoxicology
JF - Nanotoxicology
SN - 1743-5390
IS - 2
ER -