Nano-silver - feasibility and challenges for human health risk assessment based on open literature

Frans M Christensen, Helinor J Johnston, Vicki Stone, Robert J Aitken, Steve Hankin, Sheona Peters, Karin Aschberger

    Research output: Contribution to journalArticle

    Abstract

    This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also (uncontrolled) nano-silver drug intake and burn treatment of large parts of the body with wound dressings may cause risks. Main future work should focus on generating occupational and consumer exposure data, as well as toxicity data on absorption (are particles or only ions absorbed?), information on genetoxicity, and further information on the toxicity following inhalation exposure to sizes and agglomeration states as uncounted in the workplace.
    Original languageEnglish
    Pages (from-to)284-295
    Number of pages12
    JournalNanotoxicology
    Volume4
    Issue number3
    DOIs
    Publication statusPublished - 2010

    Fingerprint

    Silver
    Workplace
    Inhalation
    Inhalation Exposure
    Health
    Occupational Exposure
    Bandages
    Human Body
    Decision Making
    Ions
    Wounds and Injuries
    Pharmaceutical Preparations
    Datasets

    Keywords

    • Nano-silver
    • risk assessment
    • feasibility
    • gaps

    Cite this

    Christensen, Frans M ; Johnston, Helinor J ; Stone, Vicki ; Aitken, Robert J ; Hankin, Steve ; Peters, Sheona ; Aschberger, Karin. / Nano-silver - feasibility and challenges for human health risk assessment based on open literature. In: Nanotoxicology. 2010 ; Vol. 4, No. 3. pp. 284-295.
    @article{ed9add0a7fae4e08ad2ff4e063a06cc9,
    title = "Nano-silver - feasibility and challenges for human health risk assessment based on open literature",
    abstract = "This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also (uncontrolled) nano-silver drug intake and burn treatment of large parts of the body with wound dressings may cause risks. Main future work should focus on generating occupational and consumer exposure data, as well as toxicity data on absorption (are particles or only ions absorbed?), information on genetoxicity, and further information on the toxicity following inhalation exposure to sizes and agglomeration states as uncounted in the workplace.",
    keywords = "Nano-silver, risk assessment, feasibility, gaps",
    author = "Christensen, {Frans M} and Johnston, {Helinor J} and Vicki Stone and Aitken, {Robert J} and Steve Hankin and Sheona Peters and Karin Aschberger",
    year = "2010",
    doi = "10.3109/17435391003690549",
    language = "English",
    volume = "4",
    pages = "284--295",
    journal = "Nanotoxicology",
    issn = "1743-5390",
    publisher = "Informa Healthcare",
    number = "3",

    }

    Nano-silver - feasibility and challenges for human health risk assessment based on open literature. / Christensen, Frans M; Johnston, Helinor J; Stone, Vicki; Aitken, Robert J; Hankin, Steve; Peters, Sheona; Aschberger, Karin.

    In: Nanotoxicology, Vol. 4, No. 3, 2010, p. 284-295.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Nano-silver - feasibility and challenges for human health risk assessment based on open literature

    AU - Christensen, Frans M

    AU - Johnston, Helinor J

    AU - Stone, Vicki

    AU - Aitken, Robert J

    AU - Hankin, Steve

    AU - Peters, Sheona

    AU - Aschberger, Karin

    PY - 2010

    Y1 - 2010

    N2 - This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also (uncontrolled) nano-silver drug intake and burn treatment of large parts of the body with wound dressings may cause risks. Main future work should focus on generating occupational and consumer exposure data, as well as toxicity data on absorption (are particles or only ions absorbed?), information on genetoxicity, and further information on the toxicity following inhalation exposure to sizes and agglomeration states as uncounted in the workplace.

    AB - This study aims at investigating feasibility and challenges associated with conducting a human health risk assessment for nano-silver based on the open literature by following an approach similar to a classical regulatory risk assessment. Gaps in the available data set, both in relation to exposures and hazard, do not allow reaching any definite conclusions that could be used for regulatory decision making. Results show that repeated inhalation in the workplace and possibly consumer inhalation may cause risks. Also (uncontrolled) nano-silver drug intake and burn treatment of large parts of the body with wound dressings may cause risks. Main future work should focus on generating occupational and consumer exposure data, as well as toxicity data on absorption (are particles or only ions absorbed?), information on genetoxicity, and further information on the toxicity following inhalation exposure to sizes and agglomeration states as uncounted in the workplace.

    KW - Nano-silver

    KW - risk assessment

    KW - feasibility

    KW - gaps

    U2 - 10.3109/17435391003690549

    DO - 10.3109/17435391003690549

    M3 - Article

    C2 - 20795910

    VL - 4

    SP - 284

    EP - 295

    JO - Nanotoxicology

    JF - Nanotoxicology

    SN - 1743-5390

    IS - 3

    ER -