Mutations to nitrofurantoin and nitrofurazone resistance in Escherichia coli K12

A S Breeze, E E Obaseiki-Ebor

    Research output: Contribution to journalArticle

    Abstract

    The isolation and properties of nitrofurantoin- and nitrofurazone-resistant mutants have been compared. Nitrofurantoin-resisant mutants were easier to obtain and showed a higher resistance level. There was some cross-resistance at lower drug concentrations but not at higher levels. There was no difference in the UV resistance of most of the mutants obtained although a recB strain, AB2470, did yield nitrofurantoin-resistant mutants with increased UV resistance. This was however the only repair-defective strain which could be mutated to nitrofurantoin resistance. It is suggested that there is a mechanism for nitrofurantoin resistance in Escherichia coli K12 which does not confer resistance to nitrofurazone and which may be associated with the repair of damaged DNA. This mechanism is in addition to that which also confers resistance to nitrofurazone.

    Original languageEnglish
    Pages (from-to)99-103
    Number of pages5
    JournalJournal of General Microbiology
    Volume129
    Issue number1
    Publication statusPublished - 1983

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