Mutant PTEN in cancer: Worse than nothing

Nick R. Leslie*, Jeroen Den Hertog

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)


Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

Original languageEnglish
Pages (from-to)527-529
Number of pages3
Issue number3
Publication statusPublished - 24 Apr 2014

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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