Mutant PTEN in cancer: Worse than nothing

Nick R. Leslie, Jeroen Den Hertog

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

Original languageEnglish
Pages (from-to)527-529
Number of pages3
JournalCell
Volume157
Issue number3
DOIs
Publication statusPublished - 24 Apr 2014

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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