Mutant PTEN in cancer: Worse than nothing

Nick R. Leslie; Jeroen Den Hertog

doi:10.1016/j.cell.2014.04.008

Mutant PTEN in cancer: Worse than nothing

Nick R. Leslie^*, Jeroen Den Hertog

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

Original language	English
Pages (from-to)	527-529
Number of pages	3
Journal	Cell
Volume	157
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2014.04.008
Publication status	Published - 24 Apr 2014

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cell.2014.04.008

Cite this

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title = "Mutant PTEN in cancer: Worse than nothing",

abstract = "Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.",

author = "Leslie, {Nick R.} and {Den Hertog}, Jeroen",

year = "2014",

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T2 - Worse than nothing

AU - Leslie, Nick R.

AU - Den Hertog, Jeroen

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N2 - Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

AB - Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

U2 - 10.1016/j.cell.2014.04.008

DO - 10.1016/j.cell.2014.04.008

M3 - Article

C2 - 24766800

AN - SCOPUS:84899563338

SN - 0092-8674

VL - 157

SP - 527

EP - 529

JO - Cell

JF - Cell

IS - 3

ER -

Mutant PTEN in cancer: Worse than nothing

Abstract

ASJC Scopus subject areas

UN SDGs

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