Moving-part-free microfluidic systems for lab-on-a-chip

J. K. Luo, Y. Q. Fu, Y. Li, X. Y. Du, A. J. Flewitt, A. J. Walton, W. I. Milne

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Abstract

Microfluidic systems are part of an emerging technology which deals with minute amounts of liquids (biological samples and reagents) on a small scale. They are fast, compact and can be made into a highly integrated system to deliver sample purification, separation, reaction, immobilization, labelling, as well as detection, thus are promising for applications such as lab-on-a-chip and handheld healthcare devices. Miniaturized micropumps typically consist of a moving-part component, such as a membrane structure, to deliver liquids, and are often unreliable, complicated in structure and difficult to be integrated with other control electronics circuits. The trend of new-generation micropumps is moving-part-free micropumps operated by advanced techniques, such as electrokinetic force, surface tension/energy, acoustic waves. This paper reviews the development and advances of relevant technologies, and introduces electrowetting-on-dielectrics and acoustic wave-based microfluidics. The programmable electrowetting micropump has been realized to dispense and manipulate droplets in 2D with up to 1000 addressable electrodes and electronics built underneath. The acoustic wave-based microfluidics can be used not only for pumping, mixing and droplet generation but also for biosensors, suitable for single-mechanism-based lab-on-a-chip applications. © 2009 IOP Publishing Ltd.

Original languageEnglish
Article number054001
JournalJournal of Micromechanics and Microengineering
Volume19
Issue number5
DOIs
Publication statusPublished - 2009

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    Luo, J. K., Fu, Y. Q., Li, Y., Du, X. Y., Flewitt, A. J., Walton, A. J., & Milne, W. I. (2009). Moving-part-free microfluidic systems for lab-on-a-chip. Journal of Micromechanics and Microengineering, 19(5), [054001]. https://doi.org/10.1088/0960-1317/19/5/054001