Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case–Control Studies

Damien M. McElvenny; Laura MacCalman; Anne J. Sleeuwenhoek; Alice Davis; Brian G. Miller; Carla Alexander; Hilary Cowie; John W. Cherrie; Kathleen J. Kennedy; Nurtan A. Esmen; Sarah D. Zimmerman; Jeanine M. Buchanich; Gary M. Marsh

doi:10.1097/JOM.0000000000001036

Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case–Control Studies

Damien M. McElvenny^*, Laura MacCalman, Anne J. Sleeuwenhoek, Alice Davis, Brian G. Miller, Carla Alexander, Hilary Cowie, John W. Cherrie, Kathleen J. Kennedy, Nurtan A. Esmen, Sarah D. Zimmerman, Jeanine M. Buchanich, Gary M. Marsh

^*Corresponding author for this work

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Abstract

OBJECTIVE:: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS:: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case–control study of lung cancer was undertaken. RESULTS:: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS:: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

Original language	English
Pages (from-to)	e275–e281
Number of pages	7
Journal	Journal of Occupational and Environmental Medicine
Volume	59
Issue number	12
DOIs	https://doi.org/10.1097/JOM.0000000000001036
Publication status	Published - 1 Dec 2017

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/JOM.0000000000001036

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This is the accepted version of the following article: McElvenny, D., MacCalman, L., Sleeuwenhoek, A., Davis, A., Miller, B., Alexander, C., Cowie, H., Cherrie, J., Kennedy, K., Esmen, N., Zimmerman, S., Buchanich, J. and Marsh, G. (2017). Mortality Among Hardmetal Production Workers., which has been published in final form at https://doi.org/10.1097/JOM.0000000000001036
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McElvenny, D. M., MacCalman, L., Sleeuwenhoek, A. J., Davis, A., Miller, B. G., Alexander, C., Cowie, H., Cherrie, J. W., Kennedy, K. J., Esmen, N. A., Zimmerman, S. D., Buchanich, J. M., & Marsh, G. M. (2017). Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case–Control Studies. Journal of Occupational and Environmental Medicine, 59(12), e275–e281. https://doi.org/10.1097/JOM.0000000000001036

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abstract = "OBJECTIVE:: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS:: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case–control study of lung cancer was undertaken. RESULTS:: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS:: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.",

author = "McElvenny, {Damien M.} and Laura MacCalman and Sleeuwenhoek, {Anne J.} and Alice Davis and Miller, {Brian G.} and Carla Alexander and Hilary Cowie and Cherrie, {John W.} and Kennedy, {Kathleen J.} and Esmen, {Nurtan A.} and Zimmerman, {Sarah D.} and Buchanich, {Jeanine M.} and Marsh, {Gary M.}",

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McElvenny, DM, MacCalman, L, Sleeuwenhoek, AJ, Davis, A, Miller, BG, Alexander, C, Cowie, H, Cherrie, JW, Kennedy, KJ, Esmen, NA, Zimmerman, SD, Buchanich, JM & Marsh, GM 2017, 'Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case–Control Studies', Journal of Occupational and Environmental Medicine, vol. 59, no. 12, pp. e275–e281. https://doi.org/10.1097/JOM.0000000000001036

TY - JOUR

T1 - Mortality Among Hardmetal Production Workers

T2 - UK Cohort and Nested Case–Control Studies

AU - McElvenny, Damien M.

AU - MacCalman, Laura

AU - Sleeuwenhoek, Anne J.

AU - Davis, Alice

AU - Miller, Brian G.

AU - Alexander, Carla

AU - Cowie, Hilary

AU - Cherrie, John W.

AU - Kennedy, Kathleen J.

AU - Esmen, Nurtan A.

AU - Zimmerman, Sarah D.

AU - Buchanich, Jeanine M.

AU - Marsh, Gary M.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - OBJECTIVE:: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS:: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case–control study of lung cancer was undertaken. RESULTS:: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS:: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

AB - OBJECTIVE:: The aim of this study was to characterize the mortality at two hardmetal production factories in the United Kingdom as part of an international study. METHODS:: Standardized mortality ratios (SMRs) were calculated on the basis of mortality rates for England and Wales, and local rates. A nested case–control study of lung cancer was undertaken. RESULTS:: The cohort comprised 1538 workers, with tracing complete for 94.4%. All-cause mortality was statistically significantly low for all cancers and nonmalignant respiratory disease, and for lung cancer was nonsignificantly low. The SMR for lung cancer for maintenance workers was elevated, based on only six deaths. The odds ratio for lung cancer per year of exposure to hardmetal was 0.93 (0.76 to 1.13). CONCLUSIONS:: In this small study, there is no evidence to support that working in the UK hardmetal manufacturing industry increased mortality from any cause including lung cancer.

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Mortality Among Hardmetal Production Workers: UK Cohort and Nested Case–Control Studies

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