Molecular markers for cancer prognosis and treatment: Have we struck gold?

Somaira Nowsheen; Khaled Aziz; Mihalis I Panayiotidis; Alexandros G Georgakilas

doi:10.1016/j.canlet.2011.11.022

Molecular markers for cancer prognosis and treatment: Have we struck gold?

Somaira Nowsheen
, Khaled Aziz
, Mihalis I Panayiotidis
, Alexandros G Georgakilas

Research output: Contribution to journal › Literature review › peer-review

35 Citations (Scopus)

Abstract

The last decade has witnessed an emerging role for molecular or biochemical markers indicating a specific cellular mechanism or tissue function, often called ‘biomarkers’. Biomarkers such as altered DNA, proteins and inflammatory cytokines are critical in cancer research and strategizing treatment in the clinic. In this review we look at the application of biological indicators to cancer research and highlight their roles in cancer detection and treatment. With technological advances in gene expression, genomic and proteomic analysis, biomarker discovery is expanding fast. We focus on some of the predominantly used markers in different types of malignancies, their advantages, and their limitations. Finally we conclude by looking at the future of biomarkers, their utility in the tumorigenic studies, and the progress towards personalized treatment strategies.

Original language	English
Pages (from-to)	142-152
Number of pages	11
Journal	Cancer Letters
Volume	327
Issue number	1-2
DOIs	https://doi.org/10.1016/j.canlet.2011.11.022
Publication status	Published - 31 Dec 2012

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10.1016/j.canlet.2011.11.022

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title = "Molecular markers for cancer prognosis and treatment: Have we struck gold?",

abstract = "The last decade has witnessed an emerging role for molecular or biochemical markers indicating a specific cellular mechanism or tissue function, often called {\textquoteleft}biomarkers{\textquoteright}. Biomarkers such as altered DNA, proteins and inflammatory cytokines are critical in cancer research and strategizing treatment in the clinic. In this review we look at the application of biological indicators to cancer research and highlight their roles in cancer detection and treatment. With technological advances in gene expression, genomic and proteomic analysis, biomarker discovery is expanding fast. We focus on some of the predominantly used markers in different types of malignancies, their advantages, and their limitations. Finally we conclude by looking at the future of biomarkers, their utility in the tumorigenic studies, and the progress towards personalized treatment strategies.",

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journal = "Cancer Letters",

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TY - JOUR

T1 - Molecular markers for cancer prognosis and treatment

T2 - Have we struck gold?

AU - Nowsheen, Somaira

AU - Aziz, Khaled

AU - Panayiotidis, Mihalis I

AU - Georgakilas, Alexandros G

PY - 2012/12/31

Y1 - 2012/12/31

N2 - The last decade has witnessed an emerging role for molecular or biochemical markers indicating a specific cellular mechanism or tissue function, often called ‘biomarkers’. Biomarkers such as altered DNA, proteins and inflammatory cytokines are critical in cancer research and strategizing treatment in the clinic. In this review we look at the application of biological indicators to cancer research and highlight their roles in cancer detection and treatment. With technological advances in gene expression, genomic and proteomic analysis, biomarker discovery is expanding fast. We focus on some of the predominantly used markers in different types of malignancies, their advantages, and their limitations. Finally we conclude by looking at the future of biomarkers, their utility in the tumorigenic studies, and the progress towards personalized treatment strategies.

AB - The last decade has witnessed an emerging role for molecular or biochemical markers indicating a specific cellular mechanism or tissue function, often called ‘biomarkers’. Biomarkers such as altered DNA, proteins and inflammatory cytokines are critical in cancer research and strategizing treatment in the clinic. In this review we look at the application of biological indicators to cancer research and highlight their roles in cancer detection and treatment. With technological advances in gene expression, genomic and proteomic analysis, biomarker discovery is expanding fast. We focus on some of the predominantly used markers in different types of malignancies, their advantages, and their limitations. Finally we conclude by looking at the future of biomarkers, their utility in the tumorigenic studies, and the progress towards personalized treatment strategies.

U2 - 10.1016/j.canlet.2011.11.022

DO - 10.1016/j.canlet.2011.11.022

M3 - Literature review

C2 - 22120674

SN - 0304-3835

VL - 327

SP - 142

EP - 152

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

Molecular markers for cancer prognosis and treatment: Have we struck gold?

Abstract

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