TY - JOUR
T1 - Module number of default mode network
T2 - Inter-subject variability and effects of sleep deprivation
AU - Wang, Yulin
AU - Liu, Huan
AU - Hitchman, Glenn
AU - Lei, Xu
N1 - Funding Information:
We thank the anonymous reviewer for his/her constructive comments that improved the manuscript considerably. This research was supported by grants from the National Nature Science Foundation of China ( 31200857 ) and the Fundamental Research Funds for the Central Universities ( SWU1409241 ).
Publisher Copyright:
© 2014 Elsevier B.V. All rights reserved.
PY - 2015/1/30
Y1 - 2015/1/30
N2 - Sleep deprivation have shown its great influence on the default mode network (DMN). The DMN is a core system in resting state brain activity. Recent studies have focused on its subsystems and multiple functions. However, the individual specific organization of the DMN is rarely investigated. As the effects of sleep deprivation (SD) on mood are well documented, a more interesting question is whether changes in the processing of emotional information due to sleep deprivation are related to any specific topological properties of the DMN. In this study, we proposed an index, module number of DMN (mnDMN), to measure the specific modular structure of the DMN for each individual. Our results showed that the DMN was generally split into two modules after SD, and the decreased functional connectivity between the two modules was related to a worsening of the participants' self-reported emotional state. Furthermore, the mnDMN was correlated with participants' rating scores of high valence pictures in the SD session, indicating that the mnDMN might reflect mood valuation in the human brain. Overall, our research reveals the diversity of the DMN, and may contribute towards a better understanding of the properties and functions of the DMN.
AB - Sleep deprivation have shown its great influence on the default mode network (DMN). The DMN is a core system in resting state brain activity. Recent studies have focused on its subsystems and multiple functions. However, the individual specific organization of the DMN is rarely investigated. As the effects of sleep deprivation (SD) on mood are well documented, a more interesting question is whether changes in the processing of emotional information due to sleep deprivation are related to any specific topological properties of the DMN. In this study, we proposed an index, module number of DMN (mnDMN), to measure the specific modular structure of the DMN for each individual. Our results showed that the DMN was generally split into two modules after SD, and the decreased functional connectivity between the two modules was related to a worsening of the participants' self-reported emotional state. Furthermore, the mnDMN was correlated with participants' rating scores of high valence pictures in the SD session, indicating that the mnDMN might reflect mood valuation in the human brain. Overall, our research reveals the diversity of the DMN, and may contribute towards a better understanding of the properties and functions of the DMN.
KW - Default mode network
KW - Functional connectivity
KW - Modularity
KW - Sleep deprivation
UR - http://www.scopus.com/inward/record.url?scp=84919774179&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2014.11.007
DO - 10.1016/j.brainres.2014.11.007
M3 - Article
C2 - 25446443
AN - SCOPUS:84919774179
SN - 0006-8993
VL - 1596
SP - 69
EP - 78
JO - Brain Research
JF - Brain Research
ER -