Modulation of Host Biology by Pseudomonas aeruginosa Quorum Sensing Signal Molecules: Messengers or Traitors

Yi-Chia Liu, Kok Gan Chan, Chien-Yi Chang

    Research output: Contribution to journalArticle

    26 Citations (Scopus)
    60 Downloads (Pure)

    Abstract

    Bacterial cells sense their population density and respond accordingly by producing various signal molecules to the surrounding environments thereby trigger a plethora of gene expression. This regulatory pathway is termed quorum sensing (QS). Plenty of bacterial virulence factors are controlled by QS or QS-mediated regulatory systems and QS signal molecules (QSSMs) play crucial roles in bacterial signaling transduction. Moreover, bacterial QSSMs were shown to interfere with host cell signaling and modulate host immune responses. QSSMs not only regulate the expression of bacterial virulence factors but themselves act in the modulation of host biology that can be potential therapeutic targets.

    Original languageEnglish
    Article number1226
    JournalFrontiers in Microbiology
    Volume6
    DOIs
    Publication statusPublished - Nov 2015

    Keywords

    • Immunomodulation
    • N-acyl homoserine lactones
    • Pseudomonas aeruginosa
    • Pseudomonas quinolone signal
    • Quorum sensing

    ASJC Scopus subject areas

    • Microbiology
    • Microbiology (medical)

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