Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment

Delanyo Kpeglo; Margaret Knowles; Malcolm Haddrick; Stephen D. Evans; Sally A. Peyman

Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment

Delanyo Kpeglo, Margaret Knowles, Malcolm Haddrick, Stephen D. Evans, Sally A. Peyman^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper presents a microfluidic device for modelling the biophysics of pancreatic ductal adenocarcinoma (PDAC). The biophysics of PDAC hampers the delivery and uptake of chemotherapeutic drugs to the PDAC cancer cells. Understanding and modelling the biophysical nature of PDAC, its fibrotic stroma, and mechanical stiffness is key to effectively targeting PDAC cells with therapeutics.

Original language	English
Title of host publication	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021
Publisher	Chemical and Biological Microsystems Society
Pages	493-494
Number of pages	2
ISBN (Electronic)	9781733419031
Publication status	Published - 2021
Event	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021 - Palm Springs, Virtual, United States Duration: 10 Oct 2021 → 14 Oct 2021 https://www.microtasconferences.org/microtas2021/

Conference

Conference	25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021
Abbreviated title	MicroTAS 2021
Country/Territory	United States
City	Palm Springs, Virtual
Period	10/10/21 → 14/10/21
Internet address	https://www.microtasconferences.org/microtas2021/

Keywords

Pancreatic Ductal Adenocarcinoma
Tumour Mechanics
Tumour Microenvironment

ASJC Scopus subject areas

Bioengineering
Chemical Engineering (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@inproceedings{69e99e33f61c4941ae369629f45a5e91,

title = "Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment",

abstract = "This paper presents a microfluidic device for modelling the biophysics of pancreatic ductal adenocarcinoma (PDAC). The biophysics of PDAC hampers the delivery and uptake of chemotherapeutic drugs to the PDAC cancer cells. Understanding and modelling the biophysical nature of PDAC, its fibrotic stroma, and mechanical stiffness is key to effectively targeting PDAC cells with therapeutics.",

keywords = "Pancreatic Ductal Adenocarcinoma, Tumour Mechanics, Tumour Microenvironment",

author = "Delanyo Kpeglo and Margaret Knowles and Malcolm Haddrick and Evans, {Stephen D.} and Peyman, {Sally A.}",

note = "Publisher Copyright: {\textcopyright} 2021 MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. All rights reserved.; 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021, MicroTAS 2021 ; Conference date: 10-10-2021 Through 14-10-2021",

year = "2021",

language = "English",

pages = "493--494",

booktitle = "25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021",

publisher = "Chemical and Biological Microsystems Society",

url = "https://www.microtasconferences.org/microtas2021/",

}

Kpeglo, D, Knowles, M, Haddrick, M, Evans, SD & Peyman, SA 2021, Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment. in 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021. Chemical and Biological Microsystems Society, pp. 493-494, 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021, Palm Springs, Virtual, California, United States, 10/10/21.

Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment. / Kpeglo, Delanyo; Knowles, Margaret; Haddrick, Malcolm et al.
25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021. Chemical and Biological Microsystems Society, 2021. p. 493-494.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment

AU - Kpeglo, Delanyo

AU - Knowles, Margaret

AU - Haddrick, Malcolm

AU - Evans, Stephen D.

AU - Peyman, Sally A.

PY - 2021

Y1 - 2021

N2 - This paper presents a microfluidic device for modelling the biophysics of pancreatic ductal adenocarcinoma (PDAC). The biophysics of PDAC hampers the delivery and uptake of chemotherapeutic drugs to the PDAC cancer cells. Understanding and modelling the biophysical nature of PDAC, its fibrotic stroma, and mechanical stiffness is key to effectively targeting PDAC cells with therapeutics.

AB - This paper presents a microfluidic device for modelling the biophysics of pancreatic ductal adenocarcinoma (PDAC). The biophysics of PDAC hampers the delivery and uptake of chemotherapeutic drugs to the PDAC cancer cells. Understanding and modelling the biophysical nature of PDAC, its fibrotic stroma, and mechanical stiffness is key to effectively targeting PDAC cells with therapeutics.

KW - Pancreatic Ductal Adenocarcinoma

KW - Tumour Mechanics

KW - Tumour Microenvironment

UR - http://www.scopus.com/inward/record.url?scp=85136992657&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85136992657

SP - 493

EP - 494

BT - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021

PB - Chemical and Biological Microsystems Society

T2 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2021

Y2 - 10 October 2021 through 14 October 2021

ER -

Modelling the biophysics of pancreatic ductal adenocarcinoma on-chip for effective therapeutic assessment

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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